Pharmacology and biology of corticotropin-releasing factor (CRF) receptors

K. Eckart, O. Jahn, J. Radulovic, M. Radulovic, T. Blank, O. Stiedl, O. Brauns, H. Tezval, T. Zeyda, J. Spiess*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

The biology of corticotropin-releasing factor (CRF) finds increasing interest in the scientific community because of the neuromodulatory actions of CRF on brain functions such as learning, anxiety, feeding, and locomotion. Additional actions on immunumodulation and apoptosis have recently been discovered. All actions of CRF are mediated by G protein-coupled receptors, which trigger different, sometimes opposite actions in different regions of the central nervous system. The CRF system exhibits considerable plasticity by the involvement of numerous different ligands, splice variants, and transductional couplings. The generation of multiple splice variants is facilitated by the intron exon structure of the CRF receptor genes.

Original languageEnglish (US)
Pages (from-to)163-177
Number of pages15
JournalReceptors and Channels
Volume8
Issue number3-4
DOIs
StatePublished - Jan 1 2002

Keywords

  • Anxiety
  • Cardiovascular modulation
  • Corticotropin-releasing factor binding protein
  • Immune cells
  • Stress
  • Urocortin

ASJC Scopus subject areas

  • Pharmacology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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