@inbook{a27293e8b35148ff91075ea094ab7374,
title = "Pharmacology of mammalian olfactory receptors",
abstract = "Mammalian species have evolved a large and diverse number of odorant receptors (ORs). These proteins comprise the largest family of G-protein-coupled receptors (GPCRs) known, amounting to ~1,000 different receptors in the rodent. From the perspective of olfactory coding, the availability of such a vast number of chemosensory receptors poses several fascinating questions; in addition, such a large repertoire provides an attractive biological model to study ligand-receptor interactions. The limited functional expression of these receptors in heterologous systems, however, has greatly hampered attempts to deorphanize them. We have employed a successful approach that combines electrophysiological and imaging techniques to analyze the response pro fi les of single sensory neurons. Our approach has enabled us to characterize the {"}odor space{"} of a population of native aldehyde receptors and the molecular range of a genetically engineered receptor, OR-I7.",
keywords = "Aldehydes, Ca-Imaging, OR-I7, Olfactory receptors, Sensory neurons",
author = "Smith, {Richard S.} and Zita Peterlin and Araneda, {Ricardo C.}",
year = "2013",
doi = "10.1007/978-1-62703-377-0_15",
language = "English (US)",
isbn = "9781627033763",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "203--209",
booktitle = "Proteomics for Biomarker Discovery",
}