Pharmacology of mammalian olfactory receptors

Richard S. Smith, Zita Peterlin, Ricardo C. Araneda

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Mammalian species have evolved a large and diverse number of odorant receptors (ORs). These proteins comprise the largest family of G-protein-coupled receptors (GPCRs) known, amounting to ~1,000 different receptors in the rodent. From the perspective of olfactory coding, the availability of such a vast number of chemosensory receptors poses several fascinating questions; in addition, such a large repertoire provides an attractive biological model to study ligand-receptor interactions. The limited functional expression of these receptors in heterologous systems, however, has greatly hampered attempts to deorphanize them. We have employed a successful approach that combines electrophysiological and imaging techniques to analyze the response pro fi les of single sensory neurons. Our approach has enabled us to characterize the "odor space" of a population of native aldehyde receptors and the molecular range of a genetically engineered receptor, OR-I7.

Original languageEnglish (US)
Title of host publicationProteomics for Biomarker Discovery
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Number of pages7
ISBN (Print)9781627033763
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Aldehydes
  • Ca-Imaging
  • OR-I7
  • Olfactory receptors
  • Sensory neurons

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology


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