Core Messages: Several commonly used medications in the pediatric intensive care unit (PICU) are potentially toxic to the kidney. The kidney plays a major role in determining the absorption, distribution, metabolism, and elimination of a multitude of medications that are commonly used in the PICU. As such, dosing of these medications needs to be adjusted in critically ill children with acute kidney injury. Renal replacement therapy can affect the drug levels of commonly used medications in the PICU.
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