Phase-changing antioxidant scaffold shows promise for omentum islet transplantation: A non-human primate case study

Jacqueline A. Burke, Yunxiao Zhu, Xiaomin Zhang, Jen Post, Dixon Kaufman, Xunrong Luo, Guillermo A. Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Pancreatic islet transplant is a promising clinically-used therapy for type I diabetic and post-total pancreatectomy pancreatitis patients. Islets are transplanted in a minimally invasive procedure via the hepatic portal vein. However, the proinflammatory environment of the liver exposes islets to the instant blood-mediated inflammatory reaction and hypoxic conditions, thus making this transplantation site unideal for engraftment. As a result, islet viability is greatly reduced, and graft failure is commonplace. The omentum provides a viable alternative site for laparoscopic islet transplants. Previous studies have used a biological scaffold made from autologous plasma and thrombin.1 However, due to the inflammatory nature of a diabetic or pancreatitis patient’s own blood, this approach is unideal. Herein, we describe the use of a thermoresponsive, antioxidant macromolecule poly(polyethylene glycol citrate-co-N-isopropylacrylamide) (PPCN) to protect islets from inflammatory damage and to create an antioxidative niche for their engraftment in the omentum. Our findings support the use of PPCN for laparoscopic omentum islet transplantation to reduce inflammatory oxidative damage to islet and improve patient outcomes.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages212
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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