TY - JOUR
T1 - Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors
T2 - A pediatric brain tumor consortium study
AU - Gururangan, Sridharan
AU - Turner, Christopher D.
AU - Stewart, Clinton F.
AU - O'Shaughnessy, Melinda
AU - Kocak, Mehmet
AU - Poussaint, Tina Young
AU - Phillips, Peter C.
AU - Goldman, Stewart
AU - Packer, Roger
AU - Pollack, Ian F.
AU - Blaney, Susan M.
AU - Karsten, Verena
AU - Gerson, Stanton L.
AU - Boyett, James M.
AU - Friedman, Henry S.
AU - Kun, Larry E.
PY - 2008/2/15
Y1 - 2008/2/15
N2 - Purpose: VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors. Experimental Design: VNP40101M was given i.v. daily for 5 consecutive days every 6 weeks for up to eight cycles. Dose escalation was done independently in patients stratified based on intensity of prior therapy (moderately pretreated, stratum I; heavily pretreated, stratum II). Correlative studies included pharmacokinetics and measurement of O6-alkylguanine-DNA alkyl transferase levels in peripheral bloodmononuclear cells before and after treatment. Results: Forty-one eligible patients (stratum I,19; stratum II, 22) were enrolled on this study. The dose-limiting toxicity in 35 evaluable patients was myelosuppression, which occurred in 4 of 16 patients in stratum I and 3 of 19 patients in stratum II. Pharmacokinetic studies showed a median terminal half-life of 30 min (range, 14-39.5). The maximum tolerated dose in stratum I and II were 45 and 30 mg/m2/d daily for 5 days every 6 weeks, respectively. Peripheral blood mononuclear cells alkylguanine alkyl transferase levels did not decrease significantly after VNP40101M treatment. Central imaging review confirmed that three patients had stable disease for a median of 45 weeks (range, 37-61+) after therapy. Conclusions: The recommended dose of VNP40101Mfor phase II studies in children with brain tumors is 45 mg/m 2/d in moderately pretreated and 30 mg/m2/d in heavily pretreated patients when administered for 5 consecutive days every 6 weeks.
AB - Purpose: VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors. Experimental Design: VNP40101M was given i.v. daily for 5 consecutive days every 6 weeks for up to eight cycles. Dose escalation was done independently in patients stratified based on intensity of prior therapy (moderately pretreated, stratum I; heavily pretreated, stratum II). Correlative studies included pharmacokinetics and measurement of O6-alkylguanine-DNA alkyl transferase levels in peripheral bloodmononuclear cells before and after treatment. Results: Forty-one eligible patients (stratum I,19; stratum II, 22) were enrolled on this study. The dose-limiting toxicity in 35 evaluable patients was myelosuppression, which occurred in 4 of 16 patients in stratum I and 3 of 19 patients in stratum II. Pharmacokinetic studies showed a median terminal half-life of 30 min (range, 14-39.5). The maximum tolerated dose in stratum I and II were 45 and 30 mg/m2/d daily for 5 days every 6 weeks, respectively. Peripheral blood mononuclear cells alkylguanine alkyl transferase levels did not decrease significantly after VNP40101M treatment. Central imaging review confirmed that three patients had stable disease for a median of 45 weeks (range, 37-61+) after therapy. Conclusions: The recommended dose of VNP40101Mfor phase II studies in children with brain tumors is 45 mg/m 2/d in moderately pretreated and 30 mg/m2/d in heavily pretreated patients when administered for 5 consecutive days every 6 weeks.
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U2 - 10.1158/1078-0432.CCR-07-4242
DO - 10.1158/1078-0432.CCR-07-4242
M3 - Article
C2 - 18281546
AN - SCOPUS:39749201673
SN - 1078-0432
VL - 14
SP - 1124
EP - 1130
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 4
ER -
