Phase II study of docetaxel in the treatment of patients with advanced non-small cell lung cancer in routine daily practice

K. Mattson*, L. Bosquee, G. Dabouis, A. Le Groumellec, J. L. Pujol, S. Marien, R. Stupp, J. Y. Douillard, B. Brägas, J. Berille, R. Olivares, T. Le Chevalier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The purpose of this study was to evaluate the efficacy and safety of docetaxel as first- and second-line chemotherapy for advanced non-small cell lung cancer (NSCLC) under routine clinical conditions. Two hundred and three patients with advanced NSCLC received docetaxel 100 mg/m2 (1-h intravenous infusion) every 3 weeks, with oral corticosteroid pre-medication, of whom 173 were eligible. Median age was 60 (29-78) years and median Karnofsky performance status was 80% (60-100). A total of 77% of patients had metastatic disease, 33% had bone metastases and 18% had liver metastases. The treatment was second-line or more for 72 patients (35%). Overall response rates in the eligible population were 19.7% [95% CI, 12.5-23.0] for both treatments, 22.6% for first-line treatment and 13.8% for second-line treatment. Median survival was 8.3 months and 1-year survival was 35% for the overall population (8.7 months and 38%, respectively, for patients receiving first-line treatment and 7.2 months and 27%, respectively, for patients receiving second-line treatment). Neutropenia, grade 3 and 4, occurred in 57% of the cycles and 5% of patients experienced febrile neutropenia. Alopecia (62% of patients), neuro-sensory symptoms (32%), asthenia (28%), diarrhea (22%), nausea (22%) and nail disorders (20%) were the most common non-hematological adverse effects. A total of 33% of patients suffered fluid retention, despite the use of corticosteroid pre-medication, but this was only severe in 1.5% of patients. It was possible to confirm the efficacy of docetaxel as a single agent for first- and second-line chemotherapy in a large patient population treated in a community setting. (C) Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)205-216
Number of pages12
JournalLung Cancer
Issue number3
StatePublished - Sep 1 2000


  • Community setting
  • Docetaxel
  • First-line
  • Second-line

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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