Abstract
Background: The methotrexate analogue 10-ethyl-10-deazaaminopterin (10-EdAM, or edatrexate) has shown antitumor activity in preclinical testing and clinical studies of patients with breast, lung and head and neck carcinomas. A phase II study was conducted in patients with advanced pancreatic adenocarcinoma. Patients and methods: Forty patients were enrolled on the clinical trial. Edatrexate was administered intravenously at a dose of 80 mg/m2 weekly for 5 weeks. The treatment course was repeated every 6 weeks. Results: Two partial responses were observed. Both of these patients had partial responses which lasted 2 and 3.5 months. The median survival for all patients was 3.5 months. Serious (grade 3 or 4) toxic effects were primarily mucosal, hematologic, and dermatologic. Two patients experienced severe pulmonary toxic reactions. Conclusion: At the dose and schedule used, edatrexate was poorly tolerated and did not demonstrate significant antitumor activity.
Original language | English (US) |
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Pages (from-to) | 286-287 |
Number of pages | 2 |
Journal | Annals of Oncology |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1994 |
Keywords
- 10-EdAM
- Antimetabolite
- Edatrexate
- Folate antagonist
- Methotrexate
- Pancreatic adenocarcinoma
ASJC Scopus subject areas
- Hematology
- Oncology