Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma

Nam H. Dang; Luis Fayad; Peter McLaughlin; Jorge E. Romaguara; Fredrick Hagemeister; Andre Goy; Sattva Neelapu; Felipe Samaniego; Pamela L. Walker; Michael Wang; Maria A. Rodriguez; Ann T. Tong; Barbara Pro

doi:10.1111/j.1365-2141.2007.06684.x

Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma

Nam H. Dang^*, Luis Fayad, Peter McLaughlin, Jorge E. Romaguara, Fredrick Hagemeister, Andre Goy, Sattva Neelapu, Felipe Samaniego, Pamela L. Walker, Michael Wang, Maria A. Rodriguez, Ann T. Tong, Barbara Pro

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Denileukin diftitox plus rituximab was evaluated in relapsed/refractory B-cell non-Hodgkin lymphoma patients. Of the 38 evaluable patients, 30 (80%) were rituximab-refractory. The overall response rate (ORR) was 32%, with six complete responses (CR) and six partial responses (PR). The median time to progression for responders was 8 months (range: 2-36+); two patients with rituximab-refractory follicular lymphoma were in CR at 25 and 36+ months. The ORR was 55% (4 CRs, 2 PRs) in 11/14 patients with rituximab-refractory follicular lymphoma, and 100% in the three patients with rituximab-sensitive tumour. Most toxicities were low grade and transient, and myelotoxicity was uncommon.

Original language	English (US)
Pages (from-to)	502-505
Number of pages	4
Journal	British Journal of Haematology
Volume	138
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06684.x
State	Published - Aug 2007

Keywords

Denileukin difitox
Follicular lymphoma
Non-Hodgkin lymphoma
Rituximab

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2007.06684.x

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Dang, N. H., Fayad, L., McLaughlin, P., Romaguara, J. E., Hagemeister, F., Goy, A., Neelapu, S., Samaniego, F., Walker, P. L., Wang, M., Rodriguez, M. A., Tong, A. T., & Pro, B. (2007). Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma. British Journal of Haematology, 138(4), 502-505. https://doi.org/10.1111/j.1365-2141.2007.06684.x

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title = "Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma",

abstract = "Denileukin diftitox plus rituximab was evaluated in relapsed/refractory B-cell non-Hodgkin lymphoma patients. Of the 38 evaluable patients, 30 (80%) were rituximab-refractory. The overall response rate (ORR) was 32%, with six complete responses (CR) and six partial responses (PR). The median time to progression for responders was 8 months (range: 2-36+); two patients with rituximab-refractory follicular lymphoma were in CR at 25 and 36+ months. The ORR was 55% (4 CRs, 2 PRs) in 11/14 patients with rituximab-refractory follicular lymphoma, and 100% in the three patients with rituximab-sensitive tumour. Most toxicities were low grade and transient, and myelotoxicity was uncommon.",

keywords = "Denileukin difitox, Follicular lymphoma, Non-Hodgkin lymphoma, Rituximab",

author = "Dang, {Nam H.} and Luis Fayad and Peter McLaughlin and Romaguara, {Jorge E.} and Fredrick Hagemeister and Andre Goy and Sattva Neelapu and Felipe Samaniego and Walker, {Pamela L.} and Michael Wang and Rodriguez, {Maria A.} and Tong, {Ann T.} and Barbara Pro",

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Dang, NH, Fayad, L, McLaughlin, P, Romaguara, JE, Hagemeister, F, Goy, A, Neelapu, S, Samaniego, F, Walker, PL, Wang, M, Rodriguez, MA, Tong, AT & Pro, B 2007, 'Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma', British Journal of Haematology, vol. 138, no. 4, pp. 502-505. https://doi.org/10.1111/j.1365-2141.2007.06684.x

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AU - Dang, Nam H.

AU - Fayad, Luis

AU - McLaughlin, Peter

AU - Romaguara, Jorge E.

AU - Hagemeister, Fredrick

AU - Goy, Andre

AU - Neelapu, Sattva

AU - Samaniego, Felipe

AU - Walker, Pamela L.

AU - Wang, Michael

AU - Rodriguez, Maria A.

AU - Tong, Ann T.

AU - Pro, Barbara

PY - 2007/8

Y1 - 2007/8

N2 - Denileukin diftitox plus rituximab was evaluated in relapsed/refractory B-cell non-Hodgkin lymphoma patients. Of the 38 evaluable patients, 30 (80%) were rituximab-refractory. The overall response rate (ORR) was 32%, with six complete responses (CR) and six partial responses (PR). The median time to progression for responders was 8 months (range: 2-36+); two patients with rituximab-refractory follicular lymphoma were in CR at 25 and 36+ months. The ORR was 55% (4 CRs, 2 PRs) in 11/14 patients with rituximab-refractory follicular lymphoma, and 100% in the three patients with rituximab-sensitive tumour. Most toxicities were low grade and transient, and myelotoxicity was uncommon.

AB - Denileukin diftitox plus rituximab was evaluated in relapsed/refractory B-cell non-Hodgkin lymphoma patients. Of the 38 evaluable patients, 30 (80%) were rituximab-refractory. The overall response rate (ORR) was 32%, with six complete responses (CR) and six partial responses (PR). The median time to progression for responders was 8 months (range: 2-36+); two patients with rituximab-refractory follicular lymphoma were in CR at 25 and 36+ months. The ORR was 55% (4 CRs, 2 PRs) in 11/14 patients with rituximab-refractory follicular lymphoma, and 100% in the three patients with rituximab-sensitive tumour. Most toxicities were low grade and transient, and myelotoxicity was uncommon.

KW - Denileukin difitox

KW - Follicular lymphoma

KW - Non-Hodgkin lymphoma

KW - Rituximab

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Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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