Phase II trial of the O⁶-alkylguanine DNA alkyltransferase inhibitor O⁶-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma

Medicine and Dentistry

• Patient 100%
• Carmustine 75%
• Chemotherapy 50%
• Diseases 37%
• Nodular Melanoma 37%
• Peripheral Blood Mononuclear Cell 37%
• O6-Benzylguanine 37%
• Outpatient 25%
• Progressive Disease 25%
• Patient History of Chemotherapy 25%
• Bone Marrow Suppression 25%
• Base 25%
• Survival 25%
• Depletion 12%
• Toxicity 12%
• Programmed Cell Death 12%
• Melanoma Cell 12%
• Carbon Monoxide 12%
• Diffusing Capacity 12%
• Enalapril Maleate 12%
• DNA Damage 12%
• Guanine 12%
• 6 O Alkylguanine DNA Alkyltransferase 12%
• DLCO 12%
• Organ 12%
• Therapeutic Procedure 12%
• Lung 12%
• Position 12%

INIS

• patients 100%
• diseases 62%
• chemotherapy 50%
• melanomas 50%
• blood 37%
• dna 25%
• nitrosoureas 25%
• capacity 12%
• design 12%
• organs 12%
• toxicity 12%
• lungs 12%
• apoptosis 12%
• dna damages 12%
• adducts 12%
• guanine 12%
• carbon monoxide 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Carmustine 75%
• Diseases 37%
• Melanoma 37%
• 6 O Benzylguanine 37%
• Patient History of Chemotherapy 25%
• Bone Marrow Suppression 25%
• Phase II Trials 25%
• Survival 25%
• Base 25%
• Toxicity 12%
• Enalapril Maleate 12%
• 6 O Alkylguanine DNA Alkyltransferase 12%
• Guanine 12%
• Carbon Monoxide 12%