Abstract
The effect of phencyclidine (PCP) on rotational behavior in rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the substantia nigra was examined and compared to the effects of d-amphetamine and apomorphine. PCP, like d-amphetamine, induced ipsilateral rotation indicating a presynaptic effect on dopamine (DA) neurons whereas apomorphine, a direct acting agonist, caused contralateral rotation. Pretreatment with alpha-methyparatyrosine inhibited PCP-induced rotation approximately to the same extent as it inhibited d-amphetamine-induced rotation, but did not significantly reduce apomorphine-induced contralateral turning, further indicating that PCP has a presynaptic effect on DA neurons. Anti-cholinergic effects on PCP may also contribute to the ipsilateral rotation noted.
Original language | English (US) |
---|---|
Pages (from-to) | 1281-1288 |
Number of pages | 8 |
Journal | Life Sciences |
Volume | 24 |
Issue number | 14 |
DOIs | |
State | Published - Apr 2 1979 |
Funding
Supported in part by USPHS MHCRC 30,938 and DA recipient of USPHS RCSA MH 47,808 .
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology