Phencyclidine-induced ipsilateral rotation in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra

Richard G. Fessler*, R. David Sturgeon, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

The effect of phencyclidine (PCP) on rotational behavior in rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the substantia nigra was examined and compared to the effects of d-amphetamine and apomorphine. PCP, like d-amphetamine, induced ipsilateral rotation indicating a presynaptic effect on dopamine (DA) neurons whereas apomorphine, a direct acting agonist, caused contralateral rotation. Pretreatment with alpha-methyparatyrosine inhibited PCP-induced rotation approximately to the same extent as it inhibited d-amphetamine-induced rotation, but did not significantly reduce apomorphine-induced contralateral turning, further indicating that PCP has a presynaptic effect on DA neurons. Anti-cholinergic effects on PCP may also contribute to the ipsilateral rotation noted.

Original languageEnglish (US)
Pages (from-to)1281-1288
Number of pages8
JournalLife Sciences
Volume24
Issue number14
DOIs
StatePublished - Apr 2 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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