TY - JOUR
T1 - Phenelzine use throughout pregnancy and the puerperium
T2 - Case report, review of the literature, and management recommendations
AU - Gracious, Barbara L.
AU - Wisner, Katherine L.
PY - 1997
Y1 - 1997
N2 - Little is known about the use of monoamine oxidase inhibitors (MAOIs) during pregnancy and the postpartum period. We present a literature review with what we believe is the second case report of phenelzine exposure throughout pregnancy and the postpartum period. Potential indications for use and principles of the clinical management of the pregnant patient treated with an MAOI are also discussed and include: documenting informed consent, MAOI dose adjusting during pregnancy, monitoring of maternal and fetal outcome, and appropriate analgesia and anesthesia daring labor and delivery. Our patient tolerated phenelzine well throughout her pregnancy but experienced recurring depressive symptoms during periods of significant weight gain requiring dose adjustment. Labor, delivery, and the perinatal period progressed without complication for our patient and her infant, in whom no congenital malformation was detected. Additional case reports and animal studies of MAOI use during gestation may help determine safety and refine clinical management guidelines.
AB - Little is known about the use of monoamine oxidase inhibitors (MAOIs) during pregnancy and the postpartum period. We present a literature review with what we believe is the second case report of phenelzine exposure throughout pregnancy and the postpartum period. Potential indications for use and principles of the clinical management of the pregnant patient treated with an MAOI are also discussed and include: documenting informed consent, MAOI dose adjusting during pregnancy, monitoring of maternal and fetal outcome, and appropriate analgesia and anesthesia daring labor and delivery. Our patient tolerated phenelzine well throughout her pregnancy but experienced recurring depressive symptoms during periods of significant weight gain requiring dose adjustment. Labor, delivery, and the perinatal period progressed without complication for our patient and her infant, in whom no congenital malformation was detected. Additional case reports and animal studies of MAOI use during gestation may help determine safety and refine clinical management guidelines.
KW - Anesthesia
KW - Labor and delivery
KW - Major depression
KW - Monoamine oxidase inhibitors
KW - Phenelzine
KW - Pregnancy
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U2 - 10.1002/(SICI)1520-6394(1997)6:3<124::AID-DA6>3.0.CO;2-D
DO - 10.1002/(SICI)1520-6394(1997)6:3<124::AID-DA6>3.0.CO;2-D
M3 - Article
C2 - 9442987
AN - SCOPUS:0031426302
SN - 1091-4269
VL - 6
SP - 124
EP - 128
JO - Depression and anxiety
JF - Depression and anxiety
IS - 3
ER -