Phenotypic alteration in retroviral gene expression by leukemia-resistant thymocytes differentiating in leukemia-susceptible recipients

Syamal K. Datta*, Samuel D. Waksal, Robert S. Schwartz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

(AKR × NZB)F 1 mice possess the dominant genes, Akv-1, Akv-2, Nzv-1 a and Nzv-2 a , which determine the expression of ecotropic and xenotropic viruses. Nevertheless, their thymic lymphocytes fail to produce these agents, and these mice are resistant to leukemia. We investigated the mechanism of this cell-specific restriction in radiation chimeras. (AKR × NZB)F 1 thymocytes that had differentiated in lethally irradiated AKR recipients produced high levels of ecotropic and xenotropic viruses and showed marked amplification of MuLV antigen expression. Polytropic viruses could also be isolated from such thymocytes. These virological changes in chimeric thymocytes were donor- and host-specific and occurred only when (AKR × NZB)F 1 bone marrow cells were inoculated into AKR recipients. This inductive capacity of the host environment could be detected in irradiated AKR recipients as early as age 2 months. The phenotypic changes brought about in leukemia-resistant (AKR × NZB)F 1 thymocytes by the leukemia-susceptible AKR thymic microenvironment may be the result of a three-component inductive system.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalCell
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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