Phenotypic Properties of Liver Tumors Induced by Dehydroepiandrosterone in F‐344 Rats

M. Sambasiva Rao*, V. Subbarao, Sujata Kumar, Anjana V. Yeldandi, Janardan K. Reddy

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80–100%) lacked the marker enzymes 7‐glutamyltranspeptidase and placental form of glutathione S‐transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose‐6‐phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

Original languageEnglish (US)
Pages (from-to)1179-1183
Number of pages5
JournalJapanese Journal of Cancer Research
Volume83
Issue number11
DOIs
StatePublished - Nov 1992

Keywords

  • Glutathione S‐transferase P
  • Hepatocellular carcinoma
  • Oxidative stress
  • Peroxisome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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