Phenotypic Properties of Liver Tumors Induced by Dehydroepiandrosterone in F‐344 Rats

M. Sambasiva Rao; V. Subbarao; Sujata Kumar; Anjana V. Yeldandi; Janardan K. Reddy

doi:10.1111/j.1349-7006.1992.tb02742.x

Phenotypic Properties of Liver Tumors Induced by Dehydroepiandrosterone in F‐344 Rats

M. Sambasiva Rao^*, V. Subbarao, Sujata Kumar, Anjana V. Yeldandi, Janardan K. Reddy

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80–100%) lacked the marker enzymes 7‐glutamyltranspeptidase and placental form of glutathione S‐transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose‐6‐phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

Original language	English (US)
Pages (from-to)	1179-1183
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	83
Issue number	11
DOIs	https://doi.org/10.1111/j.1349-7006.1992.tb02742.x
State	Published - Nov 1992

Keywords

Glutathione S‐transferase P
Hepatocellular carcinoma
Oxidative stress
Peroxisome

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1992.tb02742.x

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title = "Phenotypic Properties of Liver Tumors Induced by Dehydroepiandrosterone in F‐344 Rats",

abstract = "Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80–100%) lacked the marker enzymes 7‐glutamyltranspeptidase and placental form of glutathione S‐transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose‐6‐phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.",

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author = "Rao, {M. Sambasiva} and V. Subbarao and Sujata Kumar and Yeldandi, {Anjana V.} and Reddy, {Janardan K.}",

year = "1992",

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doi = "10.1111/j.1349-7006.1992.tb02742.x",

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AU - Rao, M. Sambasiva

AU - Subbarao, V.

AU - Kumar, Sujata

AU - Yeldandi, Anjana V.

AU - Reddy, Janardan K.

PY - 1992/11

Y1 - 1992/11

N2 - Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80–100%) lacked the marker enzymes 7‐glutamyltranspeptidase and placental form of glutathione S‐transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose‐6‐phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

AB - Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80–100%) lacked the marker enzymes 7‐glutamyltranspeptidase and placental form of glutathione S‐transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose‐6‐phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

KW - Glutathione S‐transferase P

KW - Hepatocellular carcinoma

KW - Oxidative stress

KW - Peroxisome

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Phenotypic Properties of Liver Tumors Induced by Dehydroepiandrosterone in F‐344 Rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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