TY - JOUR
T1 - PHF6
T2 - It is written in the stem cells
AU - Ntziachristos, Panagiotis
N1 - Publisher Copyright:
© 2019 by The American Society of Hematology.
PY - 2019/6/6
Y1 - 2019/6/6
N2 - In the current issue of Blood, Miyagi et al investigated the role of the plant homeodomain-like finger protein 6 (PHF6) in hematopoietic stem cell (HSC) self-renewal in an attempt to further clarify the previously suggested tumor suppressive role of this protein in human leukemia.1 Interestingly, Phf6 ablation rendered HSCs less responsive to inflammatory stress signals, but was able to increase HSCs proliferation rates, which might, at least in part, contribute to oncogenic transformation (see figure).
AB - In the current issue of Blood, Miyagi et al investigated the role of the plant homeodomain-like finger protein 6 (PHF6) in hematopoietic stem cell (HSC) self-renewal in an attempt to further clarify the previously suggested tumor suppressive role of this protein in human leukemia.1 Interestingly, Phf6 ablation rendered HSCs less responsive to inflammatory stress signals, but was able to increase HSCs proliferation rates, which might, at least in part, contribute to oncogenic transformation (see figure).
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U2 - 10.1182/blood.2019000810
DO - 10.1182/blood.2019000810
M3 - Article
C2 - 31171539
AN - SCOPUS:85067424472
SN - 0006-4971
VL - 133
SP - 2461
EP - 2462
JO - Blood
JF - Blood
IS - 23
ER -