PHF6: It is written in the stem cells

Panagiotis Ntziachristos*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

In the current issue of Blood, Miyagi et al investigated the role of the plant homeodomain-like finger protein 6 (PHF6) in hematopoietic stem cell (HSC) self-renewal in an attempt to further clarify the previously suggested tumor suppressive role of this protein in human leukemia.1 Interestingly, Phf6 ablation rendered HSCs less responsive to inflammatory stress signals, but was able to increase HSCs proliferation rates, which might, at least in part, contribute to oncogenic transformation (see figure).

Original languageEnglish (US)
Pages (from-to)2461-2462
Number of pages2
JournalBlood
Volume133
Issue number23
DOIs
StatePublished - Jun 6 2019

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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