Phonological facilitation of object naming in agrammatic and logopenic primary progressive aphasia (PPA)

Jennifer E. Mack, Soojin Cho-Reyes, James D. Kloet, Sandra Weintraub, M. Marsel Mesulam, Cynthia K. Thompson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Phonological processing deficits are characteristic of both the agrammatic and logopenic subtypes of primary progressive aphasia (PPA-G and PPA-L). However, it is an open question which substages of phonological processing (i.e., phonological word form retrieval, phonological encoding) are impaired in these subtypes of PPA, as well as how phonological processing deficits contribute to anomia. In the present study, participants with PPA-G (n = 7), participants with PPA-L (n = 7), and unimpaired controls (n = 17) named objects as interfering written words (phonologically related/unrelated) were presented at different stimulus onset asynchronies (SOAs) of 0, +100, +300, and +500 ms. Phonological facilitation (PF) effects (faster naming times with phonologically related interfering words) were found for the controls and PPA-L group only at SOA = 0 and +100 ms. However, the PPA-G group exhibited protracted PF effects (PF at SOA = 0, +100, and +300 ms). These results may reflect deficits in phonological encoding in PPA-G, but not in PPA-L, supporting the neuropsychological reality of this substage of phonological processing and the distinction between these two PPA subtypes.

Original languageEnglish (US)
Pages (from-to)172-193
Number of pages22
JournalCognitive Neuropsychology
Issue number3
StatePublished - May 2013


  • Anomia
  • Phonological processing
  • Picture-word interference paradigm
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience


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