Abstract
A catalytic two-component three-centered (2C3C) Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin (DNJ) isomers using a chiron approach. This new and quite mild catalytic system, comprised of phenylphosphinic acid/NaI, was used to synthesize both the L-allo-DNJ and L-altro-DNJ in high yield.
Original language | English (US) |
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Pages (from-to) | 1503-1510 |
Number of pages | 8 |
Journal | Chinese Journal of Chemistry |
Volume | 39 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2021 |
Funding
CSA acknowledges the Tianjin University for the financial assistance. PS acknowledges the GGS IP Universality for financial assistance and TRC lab for analytical data.
Keywords
- Azasugars
- Isocyanide
- Multicomponent reactions
- Nitrilium ion
- Reductivecyclization
ASJC Scopus subject areas
- General Chemistry