Phospho-regulation of β-catenin adhesion and signaling functions

Rebecca Leadem Daugherty*, Cara J. Gottardi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

188 Scopus citations

Abstract

β-Catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which β-catenin participates in these two functions is dictated by the availability of β-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact β-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalPhysiology
Volume22
Issue number5
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Physiology

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