Phospholipase D2 mediates survival signaling through direct regulation of akt in glioblastoma cells

Ronald C. Bruntz; Harry E. Taylor; Craig W. Lindsley; H. Alex Brown

doi:10.1074/jbc.M113.532978

Phospholipase D₂ mediates survival signaling through direct regulation of akt in glioblastoma cells

Ronald C. Bruntz, Harry E. Taylor, Craig W. Lindsley, H. Alex Brown^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Background: Phospholipase D (PLD) and phosphatidic acid regulate fundamental cellular processes that contribute to cancer cell proliferation and survival. Results: Inhibition of PLD₂ decreases activation of the pro-survival kinase Akt leading to cell death through inhibition of autophagic flux. Conclusion: PLD₂ promotes autophagy through regulation of Akt in glioblastoma cells.

Original language	English (US)
Pages (from-to)	600-616
Number of pages	17
Journal	Journal of Biological Chemistry
Volume	289
Issue number	2
DOIs	https://doi.org/10.1074/jbc.M113.532978
State	Published - Jan 10 2014

Funding

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1074/jbc.M113.532978

Cite this

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title = "Phospholipase D2 mediates survival signaling through direct regulation of akt in glioblastoma cells",

abstract = "Background: Phospholipase D (PLD) and phosphatidic acid regulate fundamental cellular processes that contribute to cancer cell proliferation and survival. Results: Inhibition of PLD2 decreases activation of the pro-survival kinase Akt leading to cell death through inhibition of autophagic flux. Conclusion: PLD2 promotes autophagy through regulation of Akt in glioblastoma cells.",

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