Phospholipase D2 mediates survival signaling through direct regulation of akt in glioblastoma cells

Ronald C. Bruntz, Harry E. Taylor, Craig W. Lindsley, H. Alex Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background: Phospholipase D (PLD) and phosphatidic acid regulate fundamental cellular processes that contribute to cancer cell proliferation and survival. Results: Inhibition of PLD2 decreases activation of the pro-survival kinase Akt leading to cell death through inhibition of autophagic flux. Conclusion: PLD2 promotes autophagy through regulation of Akt in glioblastoma cells.

Original languageEnglish (US)
Pages (from-to)600-616
Number of pages17
JournalJournal of Biological Chemistry
Volume289
Issue number2
DOIs
StatePublished - Jan 10 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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