Phospholipid and fatty acid regulation of signal transduction at synapses: potential role for protein kinase C in information storage.

A. Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Protein kinase C has been proposed by the author to play a pivotal role in the storage of information. Its activation is directly related to synaptic potentiation as is phosphorylation of certain substrates such as protein F1. Protein F1 is found in highest concentration in those regions of temporal cortex critical for storage of information. The possibility is raised that pathology of this protein kinase C/protein F1 endogenous phosphorylation system may lead to or is responsible for the memory loss of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalJournal of neural transmission. Supplementum
Volume24
StatePublished - 1987

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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