Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

Ying Wang, Melina R. Kibbe*, Guillermo A. Ameer

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The delivery of nitric oxide (NO) has important applications in medicine, especially for procedures that involve the vasculature. We report photo-curable biodegradable poly(diol citrate) elastomers capable of slow release of NO. A methacrylated poly(diol citrate) macromonomer was prepared by polycondensation of citric acid with 1,8-octanediol or 1,12-dodecanediol followed by functionalization with 2-aminoethyl methacrylate. A miscible NO donor, diazeniumdiolated N,N-diethyldiethylenetriamine, was synthesized and incorporated into the polymer matrix. An elastomeric network was obtained via photo-polymerization of macromonomers upon UV irradiation within three minutes. Films and tubes of the NO-releasing crosslinked macromonomers exhibited strong tensile strength and radial compressive strength, respectively. They also exhibited cell compatibility and biodegradability in vitro. Sustained NO release under physiological conditions was achieved for at least one week. NO release enhanced the proliferation of human umbilical vein endothelial cells but inhibited the proliferation of human aortic smooth muscle cells. Photo-polymerizable NO-releasing materials provide a new approach for the localized and sustained delivery of NO to treat thrombosis and restenosis in the vasculature.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalBiomaterials Science
Volume1
Issue number6
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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