Photoacoustic ophthalmoscopy for in vivo retinal imaging

Shuliang Jiao*, Minshan Jiang, Jianming Hu, Amani Fawzi, Qifa Zhou, K. KirkShung, Carmen A. Puliafito, Hao F. Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

We have developed a non-invasive photoacoustic ophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

Original languageEnglish (US)
Pages (from-to)3967-3972
Number of pages6
JournalOptics Express
Volume18
Issue number4
DOIs
StatePublished - Feb 15 2010

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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