Photoactivatable drugs for nicotinic optopharmacology

Sambashiva Banala, Matthew C. Arvin, Nicholas M. Bannon, Xiao Tao Jin, John J. Macklin, Yong Wang, Can Peng, Guiqing Zhao, John J. Marshall, Kyle R. Gee, David L. Wokosin, Veronica J. Kim, J. Michael McIntosh, Anis Contractor, Henry A. Lester, Yevgenia Kozorovitskiy, Ryan M. Drenan*, Luke D. Lavis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of available compounds is limited. We describe a general method for caging tertiary amines by using a stable quaternary ammonium linkage that elicits a red shift in the activation wavelength. We prepared a photoactivatable nicotine (PA-Nic), uncageable via one- or two-photon excitation, that is useful to study nicotinic acetylcholine receptors (nAChRs) in different experimental preparations and spatiotemporal scales.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalNature Methods
Issue number5
StatePublished - Apr 27 2018

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Photoactivatable drugs for nicotinic optopharmacology'. Together they form a unique fingerprint.

Cite this