Photocatalyzed Direct α-Alkylation of Esters Using Styrenes

Pengzhi Wang, Anna V. Bay, Emelia J. Farnam, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A mild photocatalyzed approach to achieve the α-alkylation of esters via formation of an α -radical is disclosed here. Cesium enolates of esters were generated in situ using Cs2CO3 as a base. A subsequent photocatalyzed oxidation at the α-carbon of these enolates produced an α-radical that was added into activated alkenes. This is the first example accessing the α-carbon radical of esters in photoredox catalyed transformations.

Original languageEnglish (US)
Pages (from-to)2361-2366
Number of pages6
JournalAdvanced Synthesis and Catalysis
Issue number14
StatePublished - Jul 18 2023


  • Carbonyl compounds
  • Cesium enolates
  • Photoredox catalysis
  • α-Alkylation
  • α-Radical

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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