Photochemotherapy alone or combined with interferon alpha-2a in the treatment of cutaneous T-cell lymphoma

Henry H. Roenigk*, Timothy M. Kuzel, Alexandra P. Skoutelis, Elizabeth Springer, Gordon Yu, William Caro, Kathy Gilyon, Daina Variakojis, Karen Kaul, Paul A. Bunn, Lydia Evans, Steven T. Rosen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Eighty-two patients with either mycosis fungoides (MF) or parapsoriasis en plaques were treated with psoralens ultraviolet A light (PUVA). Clinical and histologic parameters were followed for a period from 6 months to 10 years. Complete clinical clearing of lesions was observed in 51 patients (62%) and most of them were in limited-plaque MF group or parapsoriasis en plaque. The mean total dose of PUVA for complete clearing was less for early MF. Thirty-one patients (38%) relapsed and responded to additional PUVA. Patients in early stages of the disease remained clear for up to 68 months after the first course of PUVA. Post-treatment skin biopsies with early MF showed histologic clearing. A new combination therapy for MF is presented in 15 patients. Recombinant interferon alpha-2a (Roferon-A), administered intramuscularly combined with PUVA were tested in a phase I trial. Interferon doses were from 6-30 million units three times weekly. Disease stages ranged from I-B to IV-B. Complete responses were obtained in 12 of 15 patients, and partial responses seen in 2 of 15 patients, for an overall response rate of 93%. The median duration of response exceeded 23 months (range, 3 to 25 months). All responding patients have been maintained on therapy. The dose-limiting toxicities were constitutional symptoms such as fevers and malaise (93.3%), leukopenias (40.0%), mental status changes consisting of depression and confusion (33.3%), and photosensitivity (26.6%). Interferon plus PUVA appear to be highly effective regimens for the treatment of patients with cutaneous T-cell lymphomas.

Original languageEnglish (US)
Pages (from-to)S198-S205
JournalJournal of Investigative Dermatology
Volume95
Issue number6 SUPPL.
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint Dive into the research topics of 'Photochemotherapy alone or combined with interferon alpha-2a in the treatment of cutaneous T-cell lymphoma'. Together they form a unique fingerprint.

Cite this