Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues

Quansan Yang; Tong Wei; Rose T. Yin; Mingzheng Wu; Yameng Xu; Jahyun Koo; Yeon Sik Choi; Zhaoqian Xie; Sheena W. Chen; Irawati k Kandela; Shenglian Yao; Yujun Deng; Raudel Avila; Tzu Li Liu; Wubin Bai; Yiyuan Yang; Mengdi Han; Qihui Zhang; Chad R. Haney; K. Benjamin Lee; Kedar Aras; Tong Wang; Min Ho Seo; Haiwen Luan; Seung Min Lee; Anlil Brikha; Nayereh Ghoreishi-Haack; Lori Tran; Iwona Stepien; Fraser Aird; Emily A. Waters; Xinge Yu; Anthony Banks; Gregory D. Trachiotis; John M. Torkelson; Yonggang Huang; Yevgenia Kozorovitskiy; Igor R. Efimov; John A. Rogers

doi:10.1038/s41563-021-01051-x

Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues

Quansan Yang, Tong Wei, Rose T. Yin, Mingzheng Wu, Yameng Xu, Jahyun Koo, Yeon Sik Choi, Zhaoqian Xie, Sheena W. Chen, Irawati k Kandela, Shenglian Yao, Yujun Deng, Raudel Avila, Tzu Li Liu, Wubin Bai, Yiyuan Yang, Mengdi Han, Qihui Zhang, Chad R. Haney, K. Benjamin LeeKedar Aras, Tong Wang, Min Ho Seo, Haiwen Luan, Seung Min Lee, Anlil Brikha, Nayereh Ghoreishi-Haack, Lori Tran, Iwona Stepien, Fraser Aird, Emily A. Waters, Xinge Yu, Anthony Banks, Gregory D. Trachiotis, John M. Torkelson, Yonggang Huang, Yevgenia Kozorovitskiy, Igor R. Efimov, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic–tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.

Original language	English (US)
Pages (from-to)	1559-1570
Number of pages	12
Journal	Nature materials
Volume	20
Issue number	11
DOIs	https://doi.org/10.1038/s41563-021-01051-x
State	Published - Nov 2021

Funding

This work was generously funded by the Leducq Foundation project RHYTHM and the National Institutes of Health (R01-HL141470 to I.R.E. and J.A.R.). This work made use of the NUFAB facility of Northwestern University’s NUANCE Center, which received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633); the MRSEC programme (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; the Querrey Simpson Institute for Bioelectronics; the Keck Biophysics Facility, a shared resource of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, which received support in part by the NCI Cancer Center Support (P30 CA060553); the Center for Advanced Molecular Imaging (RRID:SCR_021192); Northwestern University; and the State of Illinois, through the IIN. R.T.Y. acknowledges support from the American Heart Association (19PRE34380781). M.W. acknowledges support from the National Institutes of Health (T32 AG20506). Z.X. acknowledges support from the National Natural Science Foundation of China (12072057), LiaoNing Revitalization Talents Program (XLYC2007196) and Fundamental Research Funds for the Central Universities (DUT20RC(3)032). K.A. acknowledges support from the National Institutes of Health (5K99-HL148523-02). Y.H. acknowledges support from the National Foundation of Science (CMMI1635443). Y.K. acknowledges support from the National Institutes of Health (R01NS107539 and R01MH117111), Beckman Young Investigator Award, Rita Allen Foundation Scholar Award and Searle Scholar Award. The diagrams of the mouse body with organs in Fig. 1f were created with BioRender.com.

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1038/s41563-021-01051-x

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Yang, Q., Wei, T., Yin, R. T., Wu, M., Xu, Y., Koo, J., Choi, Y. S., Xie, Z., Chen, S. W., Kandela, I. K., Yao, S., Deng, Y., Avila, R., Liu, T. L., Bai, W., Yang, Y., Han, M., Zhang, Q., Haney, C. R., ... Rogers, J. A. (2021). Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues. Nature materials, 20(11), 1559-1570. https://doi.org/10.1038/s41563-021-01051-x

@article{6cbfa21e298149fd987612605cef7b57,

title = "Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues",

abstract = "Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic–tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.",

author = "Quansan Yang and Tong Wei and Yin, {Rose T.} and Mingzheng Wu and Yameng Xu and Jahyun Koo and Choi, {Yeon Sik} and Zhaoqian Xie and Chen, {Sheena W.} and Kandela, {Irawati k} and Shenglian Yao and Yujun Deng and Raudel Avila and Liu, {Tzu Li} and Wubin Bai and Yiyuan Yang and Mengdi Han and Qihui Zhang and Haney, {Chad R.} and {Benjamin Lee}, K. and Kedar Aras and Tong Wang and Seo, {Min Ho} and Haiwen Luan and Lee, {Seung Min} and Anlil Brikha and Nayereh Ghoreishi-Haack and Lori Tran and Iwona Stepien and Fraser Aird and Waters, {Emily A.} and Xinge Yu and Anthony Banks and Trachiotis, {Gregory D.} and Torkelson, {John M.} and Yonggang Huang and Yevgenia Kozorovitskiy and Efimov, {Igor R.} and Rogers, {John A.}",

note = "Funding Information: This work was generously funded by the Leducq Foundation project RHYTHM and the National Institutes of Health (R01-HL141470 to I.R.E. and J.A.R.). This work made use of the NUFAB facility of Northwestern University{\textquoteright}s NUANCE Center, which received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633); the MRSEC programme (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; the Querrey Simpson Institute for Bioelectronics; the Keck Biophysics Facility, a shared resource of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, which received support in part by the NCI Cancer Center Support (P30 CA060553); the Center for Advanced Molecular Imaging (RRID:SCR_021192); Northwestern University; and the State of Illinois, through the IIN. R.T.Y. acknowledges support from the American Heart Association (19PRE34380781). M.W. acknowledges support from the National Institutes of Health (T32 AG20506). Z.X. acknowledges support from the National Natural Science Foundation of China (12072057), LiaoNing Revitalization Talents Program (XLYC2007196) and Fundamental Research Funds for the Central Universities (DUT20RC(3)032). K.A. acknowledges support from the National Institutes of Health (5K99-HL148523-02). Y.H. acknowledges support from the National Foundation of Science (CMMI1635443). Y.K. acknowledges support from the National Institutes of Health (R01NS107539 and R01MH117111), Beckman Young Investigator Award, Rita Allen Foundation Scholar Award and Searle Scholar Award. The diagrams of the mouse body with organs in Fig. 1f were created with BioRender.com. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2021",

month = nov,

doi = "10.1038/s41563-021-01051-x",

language = "English (US)",

volume = "20",

pages = "1559--1570",

journal = "Nature materials",

issn = "1476-1122",

publisher = "Nature Publishing Group",

number = "11",

}

Yang, Q, Wei, T, Yin, RT, Wu, M, Xu, Y, Koo, J, Choi, YS, Xie, Z, Chen, SW, Kandela, IK, Yao, S, Deng, Y, Avila, R, Liu, TL, Bai, W, Yang, Y, Han, M, Zhang, Q, Haney, CR, Benjamin Lee, K, Aras, K, Wang, T, Seo, MH, Luan, H, Lee, SM, Brikha, A, Ghoreishi-Haack, N, Tran, L, Stepien, I, Aird, F, Waters, EA, Yu, X, Banks, A, Trachiotis, GD, Torkelson, JM , Huang, Y , Kozorovitskiy, Y , Efimov, IR & Rogers, JA 2021, 'Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues', Nature materials, vol. 20, no. 11, pp. 1559-1570. https://doi.org/10.1038/s41563-021-01051-x

TY - JOUR

T1 - Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues

AU - Yang, Quansan

AU - Wei, Tong

AU - Yin, Rose T.

AU - Wu, Mingzheng

AU - Xu, Yameng

AU - Koo, Jahyun

AU - Choi, Yeon Sik

AU - Xie, Zhaoqian

AU - Chen, Sheena W.

AU - Kandela, Irawati k

AU - Yao, Shenglian

AU - Deng, Yujun

AU - Avila, Raudel

AU - Liu, Tzu Li

AU - Bai, Wubin

AU - Yang, Yiyuan

AU - Han, Mengdi

AU - Zhang, Qihui

AU - Haney, Chad R.

AU - Benjamin Lee, K.

AU - Aras, Kedar

AU - Wang, Tong

AU - Seo, Min Ho

AU - Luan, Haiwen

AU - Lee, Seung Min

AU - Brikha, Anlil

AU - Ghoreishi-Haack, Nayereh

AU - Tran, Lori

AU - Stepien, Iwona

AU - Aird, Fraser

AU - Waters, Emily A.

AU - Yu, Xinge

AU - Banks, Anthony

AU - Trachiotis, Gregory D.

AU - Torkelson, John M.

AU - Huang, Yonggang

AU - Kozorovitskiy, Yevgenia

AU - Efimov, Igor R.

AU - Rogers, John A.

N1 - Funding Information: This work was generously funded by the Leducq Foundation project RHYTHM and the National Institutes of Health (R01-HL141470 to I.R.E. and J.A.R.). This work made use of the NUFAB facility of Northwestern University’s NUANCE Center, which received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633); the MRSEC programme (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; the Querrey Simpson Institute for Bioelectronics; the Keck Biophysics Facility, a shared resource of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, which received support in part by the NCI Cancer Center Support (P30 CA060553); the Center for Advanced Molecular Imaging (RRID:SCR_021192); Northwestern University; and the State of Illinois, through the IIN. R.T.Y. acknowledges support from the American Heart Association (19PRE34380781). M.W. acknowledges support from the National Institutes of Health (T32 AG20506). Z.X. acknowledges support from the National Natural Science Foundation of China (12072057), LiaoNing Revitalization Talents Program (XLYC2007196) and Fundamental Research Funds for the Central Universities (DUT20RC(3)032). K.A. acknowledges support from the National Institutes of Health (5K99-HL148523-02). Y.H. acknowledges support from the National Foundation of Science (CMMI1635443). Y.K. acknowledges support from the National Institutes of Health (R01NS107539 and R01MH117111), Beckman Young Investigator Award, Rita Allen Foundation Scholar Award and Searle Scholar Award. The diagrams of the mouse body with organs in Fig. 1f were created with BioRender.com. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2021/11

Y1 - 2021/11

N2 - Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic–tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.

AB - Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic–tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.

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AN - SCOPUS:85111672523

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JO - Nature materials

JF - Nature materials

IS - 11

ER -

Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues

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