TY - JOUR
T1 - Photodynamic therapy of choroidal hemangioma in sturge-weber syndrome, with a review of treatments for diffuse and circumscribed choroidal hemangiomas
AU - Tsipursky, Michael S.
AU - Golchet, Pamela R.
AU - Jampol, Lee M.
N1 - Funding Information:
The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article. Publication of this article was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York City, NY.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/1
Y1 - 2011/1
N2 - We report three new cases of patients with Sturge-Weber Syndrome and symptomatic retinal detachments from diffuse choroidal hemangiomas successfully treated with photodynamic therapy (PDT) and review medical literature on the available treatment options for choroidal hemangiomas. All patients were treated with a single session of PDT with verteporfin infused at a concentration of 6 mg/m2 and treated for 83 seconds with 689-nm Zeiss laser that was delivered with total energy level of 50 J/cm2 with an intensity of 600 mW/cm2. The exudative retinal detachment (RD) and macular edema completely resolved in all cases by 1-4 months after PDT treatment. Visual acuity improved in all three cases with diminished tumor size in the areas of treatment. One case was followed for 5 months, another for 2 years, and the third case for 6 years, with no recurrence of exudative RD. PDT is an effective treatment option for visual deterioration from exudative retinal detachment in patients with diffuse choroidal hemangiomas.
AB - We report three new cases of patients with Sturge-Weber Syndrome and symptomatic retinal detachments from diffuse choroidal hemangiomas successfully treated with photodynamic therapy (PDT) and review medical literature on the available treatment options for choroidal hemangiomas. All patients were treated with a single session of PDT with verteporfin infused at a concentration of 6 mg/m2 and treated for 83 seconds with 689-nm Zeiss laser that was delivered with total energy level of 50 J/cm2 with an intensity of 600 mW/cm2. The exudative retinal detachment (RD) and macular edema completely resolved in all cases by 1-4 months after PDT treatment. Visual acuity improved in all three cases with diminished tumor size in the areas of treatment. One case was followed for 5 months, another for 2 years, and the third case for 6 years, with no recurrence of exudative RD. PDT is an effective treatment option for visual deterioration from exudative retinal detachment in patients with diffuse choroidal hemangiomas.
KW - Age-related macular degeneration
KW - Circumscribed and diffuse choroidal hemangioma
KW - Cystoid macular edema
KW - Laser photocoagulation
KW - PDT
KW - Photodynamic therapy
KW - Preretinal fibrosis
KW - Proton beam radiotherapy
KW - Radiation therapy
KW - Stereotactic radiotherapy
KW - Transpupillary thermotherapy
KW - Verteporfin
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U2 - 10.1016/j.survophthal.2010.08.002
DO - 10.1016/j.survophthal.2010.08.002
M3 - Review article
C2 - 21074819
AN - SCOPUS:78650197880
VL - 56
SP - 68
EP - 85
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
SN - 0039-6257
IS - 1
ER -