Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion

H. A. Kenny, D. J. Bernard, T. H. Horton, T. K. Woodruff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Follicle-stimulating hormone (FSH) stimulates ovarian follicle development and the production of protein hormones including inhibin A and inhibin B. The inhibins are dimeric proteins (α-βA or α-βB) secreted by growing follicles that suppress FSH in a classical endocrine negative feedback loop. Siberian hamsters, Phodopus sungorus, exhibit seasonal variation in FSH levels. Given the role of inhibin in FSH regulation, we hypothesized that ovarian inhibin expression differs between animals reared in long (16 h light:8 h darkness) and short (6 h light:18 h darkness) photoperiods. To examine inhibin expression in animals housed under long or short photoperiods, hamster inhibin α-, βA-, and βB-subunits were cloned and used to detect and localize inhibin subunit mRNA in developing follicles. Ovarian inhibin α-subunit mRNA levels were significantly higher in long day-exposed (LD) than in short day-exposed (SD) hamsters. In addition, dimeric inhibin, as well as inhibin α-, βA-, and βB,-subunit protein levels were higher in the LD than in the SD hamster ovaries.

Original languageEnglish (US)
Pages (from-to)71-83
Number of pages13
JournalJournal of Endocrinology
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion'. Together they form a unique fingerprint.

Cite this