TY - JOUR
T1 - Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications
AU - Cho, Soojeong
AU - Lee, Byeongdu
AU - Park, Wooram
AU - Huang, Xiaoke
AU - Kim, Dong Hyun
N1 - Funding Information:
The financial support from NIH/NCI-R21CA173491 (D.-H.K.), NIH/NCI-R21CA185274 (D.-H.K.), and NIH/NIBIB-R21EB017986 (D.-H.K.) are greatly acknowledged. This work used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University.
Funding Information:
The financial support from NIH/NCI-R21CA173491 (D.-H.K.) NIH/NCI-R21CA185274 (D.-H.K.), and NIH/NIBIB-R21EB017986 (D.-H.K.) are greatly acknowledged. This work used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University.
Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/8/22
Y1 - 2018/8/22
N2 - Nanoradiosensitizers have been developed to enhance localization and precision of therapeutic radiation delivery. A specific volume of comprising surface atoms is known to be the radiosensitizing region. However, the shape-dependent local dose enhancement of nanoparticles is often underestimated and rarely reported. Here, a noble metal nanostructure, inspired by the photoperiodic day-flowers, was synthesized by metal reduction with bile acid molecules. The impact of high surface area of day-flower mimicking metallic nanoparticles (D-NP) on radiosensitizing effect was demonstrated with assays for ROS generation, cellular apoptosis, and clonogenic survival of human liver cancer cells (HepG2) cells. In comparison with lower-surface-area spherical night-flower mimicking metallic nanoparticles (N-NP), exposure of our D-NP to external beam radiation doses led to a significant increase in reactive oxygen species (ROS) production and radiosensitizing cell cycle synchronization, resulting in an enhanced cancer-cell-killing effect. In clonogenic survival studies, dose-enhancing factor (DEF) of D-NP was 16.5-fold higher than N-NP. Finally, we demonstrated in vivo feasibility of our D-NP as a potent nanoradiosensitizer and CT contrast agent for advanced image-guided radiation therapy.
AB - Nanoradiosensitizers have been developed to enhance localization and precision of therapeutic radiation delivery. A specific volume of comprising surface atoms is known to be the radiosensitizing region. However, the shape-dependent local dose enhancement of nanoparticles is often underestimated and rarely reported. Here, a noble metal nanostructure, inspired by the photoperiodic day-flowers, was synthesized by metal reduction with bile acid molecules. The impact of high surface area of day-flower mimicking metallic nanoparticles (D-NP) on radiosensitizing effect was demonstrated with assays for ROS generation, cellular apoptosis, and clonogenic survival of human liver cancer cells (HepG2) cells. In comparison with lower-surface-area spherical night-flower mimicking metallic nanoparticles (N-NP), exposure of our D-NP to external beam radiation doses led to a significant increase in reactive oxygen species (ROS) production and radiosensitizing cell cycle synchronization, resulting in an enhanced cancer-cell-killing effect. In clonogenic survival studies, dose-enhancing factor (DEF) of D-NP was 16.5-fold higher than N-NP. Finally, we demonstrated in vivo feasibility of our D-NP as a potent nanoradiosensitizer and CT contrast agent for advanced image-guided radiation therapy.
KW - cancer therapy
KW - image-guided radiotherapy
KW - metallic nanoparticles
KW - radiation
KW - radiosensitizers
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U2 - 10.1021/acsami.8b09596
DO - 10.1021/acsami.8b09596
M3 - Article
C2 - 30086228
AN - SCOPUS:85051961583
SN - 1944-8244
VL - 10
SP - 27570
EP - 27577
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 33
ER -
