Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications

Soojeong Cho, Byeongdu Lee, Wooram Park, Xiaoke Huang, Dong Hyun Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Nanoradiosensitizers have been developed to enhance localization and precision of therapeutic radiation delivery. A specific volume of comprising surface atoms is known to be the radiosensitizing region. However, the shape-dependent local dose enhancement of nanoparticles is often underestimated and rarely reported. Here, a noble metal nanostructure, inspired by the photoperiodic day-flowers, was synthesized by metal reduction with bile acid molecules. The impact of high surface area of day-flower mimicking metallic nanoparticles (D-NP) on radiosensitizing effect was demonstrated with assays for ROS generation, cellular apoptosis, and clonogenic survival of human liver cancer cells (HepG2) cells. In comparison with lower-surface-area spherical night-flower mimicking metallic nanoparticles (N-NP), exposure of our D-NP to external beam radiation doses led to a significant increase in reactive oxygen species (ROS) production and radiosensitizing cell cycle synchronization, resulting in an enhanced cancer-cell-killing effect. In clonogenic survival studies, dose-enhancing factor (DEF) of D-NP was 16.5-fold higher than N-NP. Finally, we demonstrated in vivo feasibility of our D-NP as a potent nanoradiosensitizer and CT contrast agent for advanced image-guided radiation therapy.

Original languageEnglish (US)
Pages (from-to)27570-27577
Number of pages8
JournalACS Applied Materials and Interfaces
Volume10
Issue number33
DOIs
StatePublished - Aug 22 2018

Keywords

  • cancer therapy
  • image-guided radiotherapy
  • metallic nanoparticles
  • radiation
  • radiosensitizers

ASJC Scopus subject areas

  • Materials Science(all)

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