Photopheresis: Advances and Use in Systemic Sclerosis

Alan Zhou, Jaehyuk Choi*

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Purpose of Review: Extracorporeal photochemotherapy (photopheresis, ECP) is a cell-based immunomodulatory treatment that separates leukocytes from peripheral blood, exposes them to a photosensitizing agent followed by ultraviolet A light, and then reinfuses them back into the patient. ECP has been found to be effective for graft versus host disease, transplant rejection, and various autoimmune diseases. The mechanism is not well understood but studies have shown clinical benefit in the treatment of systemic sclerosis (SSc). This review examines the ECP technique, advances in our knowledge of its mechanism, and the data supporting its use in SSc-like fibrosing diseases and in SSc itself. Recent Findings: Multiple lines of evidence support ECP use in SSc. ECP generates apoptotic cells and dendritic cells, induces production of anti-inflammatory cytokines, and increases regulatory T cell numbers. Clinical studies have generally demonstrated improvement, especially the skin, in SSc patients receiving ECP. Summary: ECP may be an effective and safe procedure for the treatment of SSc.

Original languageEnglish (US)
Article number31
JournalCurrent rheumatology reports
Volume19
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Photopheresis
Systemic Scleroderma
Photosensitizing Agents
Graft Rejection
Graft vs Host Disease
Regulatory T-Lymphocytes
Ultraviolet Rays
Dendritic Cells
Autoimmune Diseases
Leukocytes
Anti-Inflammatory Agents
Therapeutics
Cell Count
Cytokines
Skin

Keywords

  • ECP
  • Extracorporeal photochemotherapy
  • Extracorporeal photopheresis
  • SSc
  • Scleroderma
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "Photopheresis: Advances and Use in Systemic Sclerosis",
abstract = "Purpose of Review: Extracorporeal photochemotherapy (photopheresis, ECP) is a cell-based immunomodulatory treatment that separates leukocytes from peripheral blood, exposes them to a photosensitizing agent followed by ultraviolet A light, and then reinfuses them back into the patient. ECP has been found to be effective for graft versus host disease, transplant rejection, and various autoimmune diseases. The mechanism is not well understood but studies have shown clinical benefit in the treatment of systemic sclerosis (SSc). This review examines the ECP technique, advances in our knowledge of its mechanism, and the data supporting its use in SSc-like fibrosing diseases and in SSc itself. Recent Findings: Multiple lines of evidence support ECP use in SSc. ECP generates apoptotic cells and dendritic cells, induces production of anti-inflammatory cytokines, and increases regulatory T cell numbers. Clinical studies have generally demonstrated improvement, especially the skin, in SSc patients receiving ECP. Summary: ECP may be an effective and safe procedure for the treatment of SSc.",
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Photopheresis : Advances and Use in Systemic Sclerosis. / Zhou, Alan; Choi, Jaehyuk.

In: Current rheumatology reports, Vol. 19, No. 6, 31, 01.06.2017.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Photopheresis

T2 - Advances and Use in Systemic Sclerosis

AU - Zhou, Alan

AU - Choi, Jaehyuk

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Purpose of Review: Extracorporeal photochemotherapy (photopheresis, ECP) is a cell-based immunomodulatory treatment that separates leukocytes from peripheral blood, exposes them to a photosensitizing agent followed by ultraviolet A light, and then reinfuses them back into the patient. ECP has been found to be effective for graft versus host disease, transplant rejection, and various autoimmune diseases. The mechanism is not well understood but studies have shown clinical benefit in the treatment of systemic sclerosis (SSc). This review examines the ECP technique, advances in our knowledge of its mechanism, and the data supporting its use in SSc-like fibrosing diseases and in SSc itself. Recent Findings: Multiple lines of evidence support ECP use in SSc. ECP generates apoptotic cells and dendritic cells, induces production of anti-inflammatory cytokines, and increases regulatory T cell numbers. Clinical studies have generally demonstrated improvement, especially the skin, in SSc patients receiving ECP. Summary: ECP may be an effective and safe procedure for the treatment of SSc.

AB - Purpose of Review: Extracorporeal photochemotherapy (photopheresis, ECP) is a cell-based immunomodulatory treatment that separates leukocytes from peripheral blood, exposes them to a photosensitizing agent followed by ultraviolet A light, and then reinfuses them back into the patient. ECP has been found to be effective for graft versus host disease, transplant rejection, and various autoimmune diseases. The mechanism is not well understood but studies have shown clinical benefit in the treatment of systemic sclerosis (SSc). This review examines the ECP technique, advances in our knowledge of its mechanism, and the data supporting its use in SSc-like fibrosing diseases and in SSc itself. Recent Findings: Multiple lines of evidence support ECP use in SSc. ECP generates apoptotic cells and dendritic cells, induces production of anti-inflammatory cytokines, and increases regulatory T cell numbers. Clinical studies have generally demonstrated improvement, especially the skin, in SSc patients receiving ECP. Summary: ECP may be an effective and safe procedure for the treatment of SSc.

KW - ECP

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KW - Extracorporeal photopheresis

KW - SSc

KW - Scleroderma

KW - Systemic sclerosis

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