Photosensitized receptor inactivation with He-Ne laser: preliminary results

Simon Arber*, W. Zev Rymer, David Crumrine

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

Receptor inactivation by means of chromophore-conjugated receptor ligands and lasers is discussed. The results of preliminary experiments aimed at inactivation of FMRFamide receptors in snail neurons using a He-Ne laser and FMRFamide analogs conjugated with Azure B are presented. Because the conjugates synthesized apparently bound to another class of binding sites on the neuronal membrane, the FMRFamide receptor inactivation was not achieved. However, laser inactivation was demonstrated for the conjugate binding sites.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume1428
StatePublished - Jan 1 1991
EventProceedings of Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences - Los Angeles, CA, USA
Duration: Jan 23 1991Jan 24 1991

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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