TY - JOUR
T1 - Physical Activity and High-Sensitivity C-Reactive Protein. The Multi-Ethnic Study of Atherosclerosis
AU - Majka, Darcy S
AU - Chang, Rowland W
AU - Vu, Thanh Huyen T
AU - Palmas, Walter
AU - Geffken, Dominic F.
AU - Ouyang, Pamela
AU - Ni, Hanyu
AU - Liu, Kiang
N1 - Funding Information:
This research was supported by NIH grants K12 RR017707 from the National Center for Research Resources and P60 AR48098 from the National Institute of Arthritis, Musculoskeletal and Skin Diseases, as well as contracts N01-HC-95159 through N01-HC-95166 from the National Heart, Lung, and Blood Institute (NHLBI). NHLBI provided funding for the MESA study and the initial design. The initial design was later modified substantially by investigators. NHLBI participated in the review of this MESA manuscript.
PY - 2009/1
Y1 - 2009/1
N2 - Background: Previous studies have suggested an inverse relationship between physical activity and markers of inflammation such as high-sensitivity C-reactive protein (hs-CRP). However, these were inconsistent, and few examined whether race and gender influenced the relationship. This study determined a cross-sectional association between physical activity and hs-CRP level in 6142 middle-aged white, Chinese, black, and Hispanic participants enrolled in the Multi-Ethnic Study of Atherosclerosis in 2000-2002. Methods: Combined moderate and vigorous physical activity was measured by self-reported leisure, conditioning, occupational, and household activities. ANCOVA was used to assess the association between moderate/vigorous physical activity and hs-CRP by gender and race. Results: Hs-CRP was higher in women. Blacks had the highest hs-CRP, and Chinese participants had the lowest. Hs-CRP decreased across tertiles of moderate/vigorous physical activity in Hispanic men in models adjusted for age, education, study site, and physical activity questionnaire mode of administration (p=0.005) and further adjusted for smoking, infection, and aspirin use (p=0.020). The trend remained significant after further adjustment for BMI; blood pressure; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; diabetes; and the use of antihypertensive, statin, and diabetes medication (p=0.044). There was a downward trend in hs-CRP across tertiles of physical activity in black and white men, but the association was weaker. No clear trend was observed in any female racial/ethnic groups. Conclusions: These findings suggest that the association between moderate/vigorous physical activity and hs-CRP differs by race and gender. Further studies are needed to confirm this and to examine the mechanisms for these race and gender differences.
AB - Background: Previous studies have suggested an inverse relationship between physical activity and markers of inflammation such as high-sensitivity C-reactive protein (hs-CRP). However, these were inconsistent, and few examined whether race and gender influenced the relationship. This study determined a cross-sectional association between physical activity and hs-CRP level in 6142 middle-aged white, Chinese, black, and Hispanic participants enrolled in the Multi-Ethnic Study of Atherosclerosis in 2000-2002. Methods: Combined moderate and vigorous physical activity was measured by self-reported leisure, conditioning, occupational, and household activities. ANCOVA was used to assess the association between moderate/vigorous physical activity and hs-CRP by gender and race. Results: Hs-CRP was higher in women. Blacks had the highest hs-CRP, and Chinese participants had the lowest. Hs-CRP decreased across tertiles of moderate/vigorous physical activity in Hispanic men in models adjusted for age, education, study site, and physical activity questionnaire mode of administration (p=0.005) and further adjusted for smoking, infection, and aspirin use (p=0.020). The trend remained significant after further adjustment for BMI; blood pressure; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; diabetes; and the use of antihypertensive, statin, and diabetes medication (p=0.044). There was a downward trend in hs-CRP across tertiles of physical activity in black and white men, but the association was weaker. No clear trend was observed in any female racial/ethnic groups. Conclusions: These findings suggest that the association between moderate/vigorous physical activity and hs-CRP differs by race and gender. Further studies are needed to confirm this and to examine the mechanisms for these race and gender differences.
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U2 - 10.1016/j.amepre.2008.09.031
DO - 10.1016/j.amepre.2008.09.031
M3 - Article
C2 - 19013748
AN - SCOPUS:57549111021
SN - 0749-3797
VL - 36
SP - 56
EP - 62
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
IS - 1
ER -