TY - JOUR
T1 - Physical activity intervention benefits persist months post-intervention
T2 - randomized trial in breast cancer survivors
AU - Rogers, Laura Q.
AU - Courneya, Kerry S.
AU - Oster, Robert A.
AU - Anton, Philip M.
AU - Phillips, Siobhan
AU - Ehlers, Diane K.
AU - McAuley, Edward
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Purpose: Determine durable effects of the 3-month Better Exercise Adherence after Treatment for Cancer (BEAT Cancer) physical activity (PA) behavior change intervention 12 months post-baseline (i.e., 9 months after intervention completion). Methods: This 2-arm multicenter trial randomized 222 post-primary treatment breast cancer survivors to BEAT Cancer (individualized exercise and group education) vs. usual care (written materials). Assessments occurred at baseline, 3, 6, and 12 months, with the 12 months assessment reported here. Measures included PA (accelerometer, self-report), cardiorespiratory fitness, muscle strength, body mass index, Functional Assessment of Cancer Therapy (FACT), SF-36, fatigue, depression, anxiety, satisfaction with life, Pittsburgh Sleep Quality Index (PSQI), lower extremity joint dysfunction, and perceived memory. Results: Adjusted linear mixed-model analyses demonstrated statistically significant month 12 between-group differences favoring BEAT Cancer for weekly minutes of moderate-to-vigorous self-report PA (mean between-group difference (M) = 44; 95% confidence interval (CI) = 12 to 76; p =.001), fitness (M = 1.5 ml/kg/min; CI = 0.4 to 2.6; p =.01), FACT-General (M = 3.5; CI = 0.7 to 6.3; p =.014), FACT-Breast (M = 3.6; CI = 0.1 to 7.1; p =.044), social well-being (M = 1.3; CI = 0.1 to 2.5; p =.037), functional well-being (M = 1.2; CI = 0.2 to 2.3; p =.023), SF-36 vitality (M = 6.1; CI = 1.4 to 10.8; p =.011), fatigue (M = − 0.7; CI = − 1.1 to − 0.2; p =.004), satisfaction with life (M = 1.9; CI = 0.3 to 3.5; p =.019), sleep duration (M = − 0.2; CI = − 0.4 to − 0.03, p =.028), and memory (M = 1.1; CI = 0.2 to 2.1; p =.024). Conclusions: A 3-month PA intervention resulted in statistically significant and clinically important benefits compared to usual care at 12 months. Implications for Cancer Survivors: Three months of individualized and group PA counseling causes benefits detectable 9 months later. Trial registration: ClinicalTrials.gov NCT00929617 (https://clinicaltrials.gov/ct2/show/NCT00929617; registered June 29, 2009).
AB - Purpose: Determine durable effects of the 3-month Better Exercise Adherence after Treatment for Cancer (BEAT Cancer) physical activity (PA) behavior change intervention 12 months post-baseline (i.e., 9 months after intervention completion). Methods: This 2-arm multicenter trial randomized 222 post-primary treatment breast cancer survivors to BEAT Cancer (individualized exercise and group education) vs. usual care (written materials). Assessments occurred at baseline, 3, 6, and 12 months, with the 12 months assessment reported here. Measures included PA (accelerometer, self-report), cardiorespiratory fitness, muscle strength, body mass index, Functional Assessment of Cancer Therapy (FACT), SF-36, fatigue, depression, anxiety, satisfaction with life, Pittsburgh Sleep Quality Index (PSQI), lower extremity joint dysfunction, and perceived memory. Results: Adjusted linear mixed-model analyses demonstrated statistically significant month 12 between-group differences favoring BEAT Cancer for weekly minutes of moderate-to-vigorous self-report PA (mean between-group difference (M) = 44; 95% confidence interval (CI) = 12 to 76; p =.001), fitness (M = 1.5 ml/kg/min; CI = 0.4 to 2.6; p =.01), FACT-General (M = 3.5; CI = 0.7 to 6.3; p =.014), FACT-Breast (M = 3.6; CI = 0.1 to 7.1; p =.044), social well-being (M = 1.3; CI = 0.1 to 2.5; p =.037), functional well-being (M = 1.2; CI = 0.2 to 2.3; p =.023), SF-36 vitality (M = 6.1; CI = 1.4 to 10.8; p =.011), fatigue (M = − 0.7; CI = − 1.1 to − 0.2; p =.004), satisfaction with life (M = 1.9; CI = 0.3 to 3.5; p =.019), sleep duration (M = − 0.2; CI = − 0.4 to − 0.03, p =.028), and memory (M = 1.1; CI = 0.2 to 2.1; p =.024). Conclusions: A 3-month PA intervention resulted in statistically significant and clinically important benefits compared to usual care at 12 months. Implications for Cancer Survivors: Three months of individualized and group PA counseling causes benefits detectable 9 months later. Trial registration: ClinicalTrials.gov NCT00929617 (https://clinicaltrials.gov/ct2/show/NCT00929617; registered June 29, 2009).
KW - Exercise
KW - Health behavior
KW - Oncology
KW - Supportive care
KW - Survivorship
KW - Symptoms
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U2 - 10.1007/s11764-022-01329-2
DO - 10.1007/s11764-022-01329-2
M3 - Review article
C2 - 36723801
AN - SCOPUS:85147182864
SN - 1932-2259
VL - 17
SP - 1834
EP - 1846
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
IS - 6
ER -
