Abstract
Purpose: Many prostate cancer survivors experience compromised health-related quality of life (HRQOL) as a result of prostate cancer. We examined relationships between types and intensities of activity and sedentary behavior and prostate cancer-related HRQOL, overall, and by demographic, disease, and treatment characteristics. Methods: Associations between post-diagnosis activity and sedentary behavior and HRQOL domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and vitality/hormonal) were prospectively examined in men diagnosed with non-metastatic prostate cancer in the Health Professionals Follow-up Study (n = 1917) using generalized linear models. Results: After adjusting for potential confounders, higher duration of total, non-vigorous, and walking activity was associated with higher vitality/hormonal functioning scores (p-trends, <0.0001). Effects were small (d = 0.16–0.20) but approached clinical significance for men in the highest vs. lowest activity categories. Survivors who walked ≥90 min/week at a normal pace, or faster, reported higher hormone/vitality scores (p = 0.001) than men walking <90 min at an easy pace. Weightlifting was associated with increased urinary incontinence (p-trend, 0.02). Total activity was associated with higher hormone/vitality functioning in men who were ≥5 years post-treatment, had more advanced disease (Gleason score ≥7), and had ≥1 comorbid condition. No relationships were observed between vigorous activity or sedentary behavior and HRQOL. Conclusions: Increased duration of non-vigorous activity and walking post-diagnosis was positively associated with better hormone/vitality functioning. Specifically, engaging in ≥5 h of non-vigorous activity or ≥3 h of walking per week may be beneficial. Implications for Cancer Survivors: Encouraging men to engage in non-vigorous activity and walking may be helpful for managing prostate cancer-related HRQOL.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 500-511 |
| Number of pages | 12 |
| Journal | Journal of Cancer Survivorship |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 17 2015 |
Fingerprint
Keywords
- Bowel functioning
- Hormone functioning
- Physical activity
- Prostate cancer survivors
- Sedentary behavior
- Sexual functioning
- Urinary functioning
ASJC Scopus subject areas
- Oncology
- Oncology(nursing)
Cite this
}
Physical activity, sedentary behavior, and health-related quality of life in prostate cancer survivors in the health professionals follow-up study. / Phillips, Siobhan M.; Stampfer, Meir J.; Chan, June M.; Giovannucci, Edward L.; Kenfield, Stacey A.
In: Journal of Cancer Survivorship, Vol. 9, No. 3, 17.09.2015, p. 500-511.Research output: Contribution to journal › Article
TY - JOUR
T1 - Physical activity, sedentary behavior, and health-related quality of life in prostate cancer survivors in the health professionals follow-up study
AU - Phillips, Siobhan M.
AU - Stampfer, Meir J.
AU - Chan, June M.
AU - Giovannucci, Edward L.
AU - Kenfield, Stacey A.
PY - 2015/9/17
Y1 - 2015/9/17
N2 - Purpose: Many prostate cancer survivors experience compromised health-related quality of life (HRQOL) as a result of prostate cancer. We examined relationships between types and intensities of activity and sedentary behavior and prostate cancer-related HRQOL, overall, and by demographic, disease, and treatment characteristics. Methods: Associations between post-diagnosis activity and sedentary behavior and HRQOL domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and vitality/hormonal) were prospectively examined in men diagnosed with non-metastatic prostate cancer in the Health Professionals Follow-up Study (n = 1917) using generalized linear models. Results: After adjusting for potential confounders, higher duration of total, non-vigorous, and walking activity was associated with higher vitality/hormonal functioning scores (p-trends, <0.0001). Effects were small (d = 0.16–0.20) but approached clinical significance for men in the highest vs. lowest activity categories. Survivors who walked ≥90 min/week at a normal pace, or faster, reported higher hormone/vitality scores (p = 0.001) than men walking <90 min at an easy pace. Weightlifting was associated with increased urinary incontinence (p-trend, 0.02). Total activity was associated with higher hormone/vitality functioning in men who were ≥5 years post-treatment, had more advanced disease (Gleason score ≥7), and had ≥1 comorbid condition. No relationships were observed between vigorous activity or sedentary behavior and HRQOL. Conclusions: Increased duration of non-vigorous activity and walking post-diagnosis was positively associated with better hormone/vitality functioning. Specifically, engaging in ≥5 h of non-vigorous activity or ≥3 h of walking per week may be beneficial. Implications for Cancer Survivors: Encouraging men to engage in non-vigorous activity and walking may be helpful for managing prostate cancer-related HRQOL.
AB - Purpose: Many prostate cancer survivors experience compromised health-related quality of life (HRQOL) as a result of prostate cancer. We examined relationships between types and intensities of activity and sedentary behavior and prostate cancer-related HRQOL, overall, and by demographic, disease, and treatment characteristics. Methods: Associations between post-diagnosis activity and sedentary behavior and HRQOL domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and vitality/hormonal) were prospectively examined in men diagnosed with non-metastatic prostate cancer in the Health Professionals Follow-up Study (n = 1917) using generalized linear models. Results: After adjusting for potential confounders, higher duration of total, non-vigorous, and walking activity was associated with higher vitality/hormonal functioning scores (p-trends, <0.0001). Effects were small (d = 0.16–0.20) but approached clinical significance for men in the highest vs. lowest activity categories. Survivors who walked ≥90 min/week at a normal pace, or faster, reported higher hormone/vitality scores (p = 0.001) than men walking <90 min at an easy pace. Weightlifting was associated with increased urinary incontinence (p-trend, 0.02). Total activity was associated with higher hormone/vitality functioning in men who were ≥5 years post-treatment, had more advanced disease (Gleason score ≥7), and had ≥1 comorbid condition. No relationships were observed between vigorous activity or sedentary behavior and HRQOL. Conclusions: Increased duration of non-vigorous activity and walking post-diagnosis was positively associated with better hormone/vitality functioning. Specifically, engaging in ≥5 h of non-vigorous activity or ≥3 h of walking per week may be beneficial. Implications for Cancer Survivors: Encouraging men to engage in non-vigorous activity and walking may be helpful for managing prostate cancer-related HRQOL.
KW - Bowel functioning
KW - Hormone functioning
KW - Physical activity
KW - Prostate cancer survivors
KW - Sedentary behavior
KW - Sexual functioning
KW - Urinary functioning
UR - http://www.scopus.com/inward/record.url?scp=84939263728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939263728&partnerID=8YFLogxK
U2 - 10.1007/s11764-015-0426-2
DO - 10.1007/s11764-015-0426-2
M3 - Article
C2 - 25876555
AN - SCOPUS:84939263728
VL - 9
SP - 500
EP - 511
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
SN - 1932-2259
IS - 3
ER -