Abstract
Physical activity is associated with circulating 25-hydroxyvitamin D (25(OH)D). However, the influence of activity and/or sedentary behavior on the biologically active, seco-steroid hormone 1α,25-dihydroxyvitamin D (1,25(OH)2D) is unknown. We conducted a cross-sectional analysis among ursodeoxycholic acid (UDCA) randomized trial participants (n=876) to evaluate associations between physical activity, sedentary behavior, and circulating vitamin D metabolite concentrations. Continuous vitamin D metabolite measurements and clinical thresholds were evaluated using multiple linear and logistic regression models, mutually adjusted for either 1,25(OH)2D or 25(OH)D and additional confounding factors. A statistically significant linear association between 1,25(OH)2D and moderate-vigorous physical activity per week was strongest among women (β (95% CI): 3.10 (1.51-6.35)) versus men (β (95% CI): 1.35 (0.79-2.29)) in the highest tertile of activity compared to the lowest (p-interaction=0.003). Furthermore, 25(OH)D was 1.54ng/ml (95% CI 1.09-1.98) higher per hour increase in moderate-vigorous activity (p=0.001) and odds of sufficient 25(OH)D status was higher among physically active participants (p=0.001). Sedentary behavior was not significantly associated with either metabolite in linear regression models, nor was a statistically significant interaction by sex identified. The current study identified novel associations between physical activity and serum 1,25(OH)2D levels, adjusted for 25(OH)D concentrations. These results identify the biologically active form of vitamin D as a potential physiologic mechanism related to observed population-level associations between moderate-vigorous physical activity with bone health and chronic disease risk. However, future longitudinal studies are needed to further evaluate the role of physical activity and vitamin D metabolites in chronic disease prevention.
Original language | English (US) |
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Pages (from-to) | 248-255 |
Number of pages | 8 |
Journal | Bone |
Volume | 83 |
DOIs | |
State | Published - Feb 1 2016 |
Funding
This work was supported by Public Health Service grants R01 CA140285, CA-110814, CA-41108, CA-23074, and CA-77145 at University of Arizona and R25 CA-160056 at Vanderbilt University. EH was responsible for study design, data analysis, and manuscript preparation. EJ and DQ contributed to the study design, data analysis, and manuscript preparation. All co-authors (CSM, QD, LK, SWA, PJ, and EJ) contributed to the data interpretation and manuscript revision. All authors approved the final version of this manuscript.
Keywords
- 1α,25-dihydoxyvitamin D
- 25-hydroxyvitamin D
- Physical activity
- Sedentary behavior
- Vitamin D
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Physiology
- Histology