Physical Determinants of Diastolic Flow

Zoran B. Popović, James D. Thomas

Research output: Chapter in Book/Report/Conference proceedingChapter


The major function of the heart in diastole is to let the blood column flow from the antechambers into the main chambers, while keeping filling pressures to a minimum. During exercise, this task is compounded by shortening of time allowed for filling and increase of volume needed to enter into the cardiac chambers. The three major parameters that define diastole are chamber stiffness, relaxation, and early diastolic suction. We describe the physical determinants of these parameters.

Original languageEnglish (US)
Title of host publicationDiastology
Subtitle of host publicationClinical Approach to Heart Failure with Preserved Ejection Fraction
Number of pages18
ISBN (Electronic)9780323640671
StatePublished - Jan 1 2020


  • Computer modeling
  • Diastolic function
  • Intraventricular pressure gradient
  • Left ventricular stiffness
  • Relaxation
  • Vorticeal flow

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Physical Determinants of Diastolic Flow'. Together they form a unique fingerprint.

Cite this