Abstract
Advances in molecular biology, optics, genetics, and bioinformatics have opened the door to mapping, in molecular detail, processes inside living cells. With the ability to observe the individual moving parts of cellular machinery, concepts formerly confined to physics are entering mainstream biology. This article discusses a few ideas of this sort related to chromosome biology, to illustrate what kinds of insights physics might yet bring to our understanding of living systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 621-631 |
| Number of pages | 11 |
| Journal | Journal of Molecular Biology |
| Volume | 432 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 17 2020 |
Funding
I thank the CNRS and Drs. J.-M. Victor and M. Barbi for supporting my stay at SU, and Dr. H. Brandao, Prof. C. Brangwynne, and Prof. A. Zidovska for their thoughtful comments. This work was supported by NIH grants GM105847 , CA193419 (NU-PS-OC), and by subcontract to DK107980 (4DN). I thank the CNRS and Drs. J.-M. Victor and M. Barbi for supporting my stay at SU, and Dr. H. Brandao, Prof. C. Brangwynne, and Prof. A. Zidovska for their thoughtful comments. This work was supported by NIH grants GM105847, CA193419 (NU-PS-OC), and by subcontract to DK107980 (4DN).
Keywords
- chromatin
- chromosomes
- phase separation
- polymer biophysics
- quantitative biology
ASJC Scopus subject areas
- Molecular Biology
- Structural Biology