Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis

M. Sanjak, D. Paulson, R. Sufit, W. Reddan, D. Beaulieu, L. Erickson, A. Shug, B. R. Brooks*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Physical work capacity in 35 ALS patients and 6 untrained controls was evaluated during proqessive bicycle ergometery. In the ALS patients, maximum oxygen consumption (VO2max) and work capacity (Wmax) drop in relation to the decrease in ALS functional score. However, the oxygen cost (ml O2/ kpm) of submaximal exercise was significantly increased. Prolonged submaximal exercise tests in six ALS patients and six matched untrained controls indicated that the exercise-induced increase in plasma free fatty acids, beta-hydroxybuty-rate, esterified carnitine, and muscle esterified carnitine was significantly retarded in ALS patients.

Original languageEnglish (US)
Pages (from-to)1217-1220
Number of pages4
JournalNeurology
Volume37
Issue number7
DOIs
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Clinical Neurology

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