Physiologic and pharmacologic implications of fibrinolysis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


According to the thrombogenetic (encrustation) theory of atherogenesis first postulated by Rokitansky, accretions of blood components including fibrin and platelets may be the initial event. Since fibrinolysis has a profound influence on the resolution of fibrin deposits, the role of fibrinolysis in atherogenesis is discussed. Evidences supporting this role include the demonstration of enhanced experimental atheroma formation by the administration of inhibitors of fibrinolysis, decreased circulating fibrinolytic activity in patients who are atherosclerotic, and inhibition of circulating fibrinolytic activity by several atherosclerosis-risk factors, such as increasing age, cigarette smoking, hypercholesterolemia, hypertriglyceridemia and diabetes mellitus. It is concluded that a combination of systemic inhibitions of fibrinolysis over a long-term period and a local vascular injury, play a decided role in atherogenesis.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
Issue number3
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Physiologic and pharmacologic implications of fibrinolysis'. Together they form a unique fingerprint.

Cite this