Picornavirus infection leading to immunosuppression

Matthew F. Cusick*, Jane E. Libbey, Robert S. Fujinami

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Viruses, such as HIV, hepatitis A, poliovirus, coxsackievirus B3 and foot-and-mouth disease virus, use a variety of mechanisms to suppress the human immune system in order to evade clearance by the host. Therefore, investigating how a few changes in the viral genome of a nonlethal virus can lead to an alteration in disease, from survivable to immunosuppression and death, would provide valuable information into viral pathogenesis. In addition, we propose that gaining a better insight into how these viruses suppress an antiviral immune response could lead to viral-based therapeutics to combat specific autoimmune diseases such as multiple sclerosis and Type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalFuture Virology
Volume9
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Picornavirus
  • T cell
  • Theiler's virus
  • autoimmune disease
  • immunosuppression

ASJC Scopus subject areas

  • Virology

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