Picosecond Fluorescence Studies of Polypeptide Dynamics

Lin X.Q. Chen*, Jacob W. Petrich, Angelo Perico, Graham R. Fleming

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Fluorescence anisotropies for single tryptophan-containing polypeptide hormones ACTH and glucagon, and a series of their fragments are studied. The data are discussed in the context of the theory of Perico and Guenza (J. Chem. Phys. 84, 510 (1986)) and a persistence length of about 7 to 10 residues obtained for the mobilities in the two hormones. Theory is able to account for chain length and probe location effects very well. The observed discrepencies between calculated and measured anisotropy decays very likely arise from approximations made in the calculation and from the limited time resolution of the experiments.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jun 24 1988
EventTime-Resolved Laser Spectroscopy in Biochemistry 1988 - Los Angeles, United States
Duration: Jan 11 1988Jan 17 1988

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Picosecond Fluorescence Studies of Polypeptide Dynamics'. Together they form a unique fingerprint.

Cite this