Pigment epithelium-derived factor as a multifunctional antitumor factor

N. I. Fernandez-Garcia, O. V. Volpert, B. Jimenez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The design of new therapeutic strategies for cancer treatment is based on the combination of drugs directed against different tumor compartments, including the tumor cells themselves and components of the stroma, such as the tumor vasculature. Indeed, several antiangiogenic compounds have entered clinical trials for use alone or in combination with conventional cytotoxic drugs. Pigment epithelium-derived factor (PEDF) is a multifunctional natural peptide with complex neurotrophic, neuroprotective, antiangiogenic, and proapoptotic biological activities, any of which could potentially be exploited for therapeutic purposes. This review summarizes recent studies that reveal the antitumor potential of PEDF based on its antiangiogenic properties and its newly discovered direct antitumor effects, which involve the induction of differentiation or apoptosis in tumor cells. We also discuss possible therapeutic applications of PEDF, based on these mechanistic insights and on the identification of functional domains that retain specific biological activities.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalJournal of Molecular Medicine
Volume85
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Antiangiogenic factors
  • New cancer therapeutics
  • Pigment epithelium-derived factor
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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