Pindolol pretreatment blocks stimulation by meta-chlorophenylpiperazine of prolactin but not cortisol secretion in normal men

Herbert Y. Meltzer; Michael Maes

doi:10.1016/0165-1781(95)02701-W

Pindolol pretreatment blocks stimulation by meta-chlorophenylpiperazine of prolactin but not cortisol secretion in normal men

Herbert Y. Meltzer^*, Michael Maes

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Previous reports from this laboratory have shown that pindolol, a partial serotonin_1A receptor agonist, inhibited prolactin, but not cortisol secretion induced by administration of the serotonin (5-HT) precursor l-5-hydroxytryptophan or the direct-acting 5-HT_2A 5HT_2C receptor agonist MK-212. The findings suggest additive or interactive effects of 5-HT_1A and 5-HT_2A 5-HT_2C receptors in modulating 5-HT-related prolactin, but not cortisol, responsivity. To examine further the role of 5-HT_1A and 5-HT_2A 5-HT_2C receptors in prolactin and cortisol secretion in healthy men, the effects of meta-chlorophenylpiperazine (mCPP), a potent 5-HT receptor agonist, on the above hormones were studied in eight healthy men with and without pindolol pretreatment. It has previously been demonstrated that ketanserin, a 5-HT_2A antagonist, and ritanserin, a 5-HT_2A 5-HT_2C antagonist, block the prolactin and attenuate the hypothalamic-pituitary-adrenal axis responses to mCPP in man or rodents. Administration of mCPP induced a significant increase in plasma concentrations of prolactin and cortisol. The mCPP-induced prolactin concentrations were significantly blocked by pretreatment with pindolol, whereas mCPP-stimulated cortisol levels were not diminished by pindolol pretreatment. Thus, mCPP-induced prolactin secretion appears to require the availability of both 5-HT_2C and 5-HT_1A receptor activation, since blockade of either of these receptors may diminish the mCPP-induced prolactin response. Cortisol secretion stimulated by mCPP may occur following 5-HT_2C receptor stimulation in the presence of 5-HT_1A receptor blockade.

Original language	English (US)
Pages (from-to)	89-98
Number of pages	10
Journal	Psychiatry Research
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(95)02701-W
State	Published - Sep 29 1995

Funding

The researchre portedw ass upportedin part by U.S. Public Health Service grant MH-41684, GCRC MO1R R00080f rom theN ational Institute of MentalH ealtha ndb y grantsf rom theE lisabeth SeverancPer entissa ndJohn PascalS awyerF oun-dations, and the Michael Kaplen Investigator Award to M. Maes. H.Y.M. is the recipiento f a U.S. Public HealthS erviceR esearchC areerS cien-tist Award MH-47808f rom the National Institute of Mental Health. The secretariala ssistanceo f Mrs. M. Maes and Ms. Lee Mason is greatly appreciated.

Keywords

Hormones
Hypothalamic-pituitary-adrenal axis
Serotonin receptor subtypes

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(95)02701-W

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title = "Pindolol pretreatment blocks stimulation by meta-chlorophenylpiperazine of prolactin but not cortisol secretion in normal men",

abstract = "Previous reports from this laboratory have shown that pindolol, a partial serotonin1A receptor agonist, inhibited prolactin, but not cortisol secretion induced by administration of the serotonin (5-HT) precursor l-5-hydroxytryptophan or the direct-acting 5-HT2A 5HT2C receptor agonist MK-212. The findings suggest additive or interactive effects of 5-HT1A and 5-HT2A 5-HT2C receptors in modulating 5-HT-related prolactin, but not cortisol, responsivity. To examine further the role of 5-HT1A and 5-HT2A 5-HT2C receptors in prolactin and cortisol secretion in healthy men, the effects of meta-chlorophenylpiperazine (mCPP), a potent 5-HT receptor agonist, on the above hormones were studied in eight healthy men with and without pindolol pretreatment. It has previously been demonstrated that ketanserin, a 5-HT2A antagonist, and ritanserin, a 5-HT2A 5-HT2C antagonist, block the prolactin and attenuate the hypothalamic-pituitary-adrenal axis responses to mCPP in man or rodents. Administration of mCPP induced a significant increase in plasma concentrations of prolactin and cortisol. The mCPP-induced prolactin concentrations were significantly blocked by pretreatment with pindolol, whereas mCPP-stimulated cortisol levels were not diminished by pindolol pretreatment. Thus, mCPP-induced prolactin secretion appears to require the availability of both 5-HT2C and 5-HT1A receptor activation, since blockade of either of these receptors may diminish the mCPP-induced prolactin response. Cortisol secretion stimulated by mCPP may occur following 5-HT2C receptor stimulation in the presence of 5-HT1A receptor blockade.",

keywords = "Hormones, Hypothalamic-pituitary-adrenal axis, Serotonin receptor subtypes",

author = "Meltzer, {Herbert Y.} and Michael Maes",

note = "Funding Information: The researchre portedw ass upportedin part by U.S. Public Health Service grant MH-41684, GCRC MO1R R00080f rom theN ational Institute of MentalH ealtha ndb y grantsf rom theE lisabeth SeverancPer entissa ndJohn PascalS awyerF oun-dations, and the Michael Kaplen Investigator Award to M. Maes. H.Y.M. is the recipiento f a U.S. Public HealthS erviceR esearchC areerS cien-tist Award MH-47808f rom the National Institute of Mental Health. The secretariala ssistanceo f Mrs. M. Maes and Ms. Lee Mason is greatly appreciated.",

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doi = "10.1016/0165-1781(95)02701-W",

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pages = "89--98",

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AU - Meltzer, Herbert Y.

AU - Maes, Michael

N1 - Funding Information: The researchre portedw ass upportedin part by U.S. Public Health Service grant MH-41684, GCRC MO1R R00080f rom theN ational Institute of MentalH ealtha ndb y grantsf rom theE lisabeth SeverancPer entissa ndJohn PascalS awyerF oun-dations, and the Michael Kaplen Investigator Award to M. Maes. H.Y.M. is the recipiento f a U.S. Public HealthS erviceR esearchC areerS cien-tist Award MH-47808f rom the National Institute of Mental Health. The secretariala ssistanceo f Mrs. M. Maes and Ms. Lee Mason is greatly appreciated.

PY - 1995/9/29

Y1 - 1995/9/29

N2 - Previous reports from this laboratory have shown that pindolol, a partial serotonin1A receptor agonist, inhibited prolactin, but not cortisol secretion induced by administration of the serotonin (5-HT) precursor l-5-hydroxytryptophan or the direct-acting 5-HT2A 5HT2C receptor agonist MK-212. The findings suggest additive or interactive effects of 5-HT1A and 5-HT2A 5-HT2C receptors in modulating 5-HT-related prolactin, but not cortisol, responsivity. To examine further the role of 5-HT1A and 5-HT2A 5-HT2C receptors in prolactin and cortisol secretion in healthy men, the effects of meta-chlorophenylpiperazine (mCPP), a potent 5-HT receptor agonist, on the above hormones were studied in eight healthy men with and without pindolol pretreatment. It has previously been demonstrated that ketanserin, a 5-HT2A antagonist, and ritanserin, a 5-HT2A 5-HT2C antagonist, block the prolactin and attenuate the hypothalamic-pituitary-adrenal axis responses to mCPP in man or rodents. Administration of mCPP induced a significant increase in plasma concentrations of prolactin and cortisol. The mCPP-induced prolactin concentrations were significantly blocked by pretreatment with pindolol, whereas mCPP-stimulated cortisol levels were not diminished by pindolol pretreatment. Thus, mCPP-induced prolactin secretion appears to require the availability of both 5-HT2C and 5-HT1A receptor activation, since blockade of either of these receptors may diminish the mCPP-induced prolactin response. Cortisol secretion stimulated by mCPP may occur following 5-HT2C receptor stimulation in the presence of 5-HT1A receptor blockade.

AB - Previous reports from this laboratory have shown that pindolol, a partial serotonin1A receptor agonist, inhibited prolactin, but not cortisol secretion induced by administration of the serotonin (5-HT) precursor l-5-hydroxytryptophan or the direct-acting 5-HT2A 5HT2C receptor agonist MK-212. The findings suggest additive or interactive effects of 5-HT1A and 5-HT2A 5-HT2C receptors in modulating 5-HT-related prolactin, but not cortisol, responsivity. To examine further the role of 5-HT1A and 5-HT2A 5-HT2C receptors in prolactin and cortisol secretion in healthy men, the effects of meta-chlorophenylpiperazine (mCPP), a potent 5-HT receptor agonist, on the above hormones were studied in eight healthy men with and without pindolol pretreatment. It has previously been demonstrated that ketanserin, a 5-HT2A antagonist, and ritanserin, a 5-HT2A 5-HT2C antagonist, block the prolactin and attenuate the hypothalamic-pituitary-adrenal axis responses to mCPP in man or rodents. Administration of mCPP induced a significant increase in plasma concentrations of prolactin and cortisol. The mCPP-induced prolactin concentrations were significantly blocked by pretreatment with pindolol, whereas mCPP-stimulated cortisol levels were not diminished by pindolol pretreatment. Thus, mCPP-induced prolactin secretion appears to require the availability of both 5-HT2C and 5-HT1A receptor activation, since blockade of either of these receptors may diminish the mCPP-induced prolactin response. Cortisol secretion stimulated by mCPP may occur following 5-HT2C receptor stimulation in the presence of 5-HT1A receptor blockade.

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Pindolol pretreatment blocks stimulation by meta-chlorophenylpiperazine of prolactin but not cortisol secretion in normal men

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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