Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma - A review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features

Matthew Jurczyk, Joseph F. Peevey, Mark A. Vande Haar, Xiaoqi Lin*

*Corresponding author for this work

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of MBCA in a 67-year-old female that was originally misinterpreted as adenoid cystic carcinoma (ACC) on FNA cytology. The FNA smears showed numerous uniform small basaloid epithelial cells with round or oval nuclei and inconspicuous nucleoli, and scant cytoplasm. The basaloid cells surround acellular, dense, homogenous material or are surrounded by acellular or paucicellular dense homogeneous material possibly containing bland spindle cells. The basaloid cells are present in variably sized three-dimensional clusters, acini, or sheets with variable cohesion. The dense homogenous material surrounded by basaloid cells may be interconnected. High power magnification reveals the homogeneous material to have a fibrillar texture. The edges of dense homogenous materials were well-demarcated. We describe the diagnostic pitfalls of FNA for MBCA, particularly versus ACC, basal cell adenoma, cellular pleomorphic adenoma, myoepithelioma, basal cell adenocarcinoma, and basaloid squamous cell carcinoma in hope of improving clinical management and patient treatment. Diagn. Cytopathol. 2015;43:432-437.

Original languageEnglish (US)
Pages (from-to)432-437
Number of pages6
JournalDiagnostic Cytopathology
Volume43
Issue number5
DOIs
StatePublished - May 1 2015

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Salivary Gland Neoplasms
Fine Needle Biopsy
Adenoma
Cell Biology
Adenoid Cystic Carcinoma
Myoepithelioma
Pleomorphic Adenoma
Squamous Cell Carcinoma
Cytoplasm
Adenocarcinoma
Epithelial Cells

Keywords

  • adenoid cystic carcinoma
  • fine-needle aspiration
  • membranous basal cell adenoma
  • parotid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

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title = "Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma - A review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features",
abstract = "Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of MBCA in a 67-year-old female that was originally misinterpreted as adenoid cystic carcinoma (ACC) on FNA cytology. The FNA smears showed numerous uniform small basaloid epithelial cells with round or oval nuclei and inconspicuous nucleoli, and scant cytoplasm. The basaloid cells surround acellular, dense, homogenous material or are surrounded by acellular or paucicellular dense homogeneous material possibly containing bland spindle cells. The basaloid cells are present in variably sized three-dimensional clusters, acini, or sheets with variable cohesion. The dense homogenous material surrounded by basaloid cells may be interconnected. High power magnification reveals the homogeneous material to have a fibrillar texture. The edges of dense homogenous materials were well-demarcated. We describe the diagnostic pitfalls of FNA for MBCA, particularly versus ACC, basal cell adenoma, cellular pleomorphic adenoma, myoepithelioma, basal cell adenocarcinoma, and basaloid squamous cell carcinoma in hope of improving clinical management and patient treatment. Diagn. Cytopathol. 2015;43:432-437.",
keywords = "adenoid cystic carcinoma, fine-needle aspiration, membranous basal cell adenoma, parotid",
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Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma - A review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features. / Jurczyk, Matthew; Peevey, Joseph F.; Vande Haar, Mark A.; Lin, Xiaoqi.

In: Diagnostic Cytopathology, Vol. 43, No. 5, 01.05.2015, p. 432-437.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma - A review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features

AU - Jurczyk, Matthew

AU - Peevey, Joseph F.

AU - Vande Haar, Mark A.

AU - Lin, Xiaoqi

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of MBCA in a 67-year-old female that was originally misinterpreted as adenoid cystic carcinoma (ACC) on FNA cytology. The FNA smears showed numerous uniform small basaloid epithelial cells with round or oval nuclei and inconspicuous nucleoli, and scant cytoplasm. The basaloid cells surround acellular, dense, homogenous material or are surrounded by acellular or paucicellular dense homogeneous material possibly containing bland spindle cells. The basaloid cells are present in variably sized three-dimensional clusters, acini, or sheets with variable cohesion. The dense homogenous material surrounded by basaloid cells may be interconnected. High power magnification reveals the homogeneous material to have a fibrillar texture. The edges of dense homogenous materials were well-demarcated. We describe the diagnostic pitfalls of FNA for MBCA, particularly versus ACC, basal cell adenoma, cellular pleomorphic adenoma, myoepithelioma, basal cell adenocarcinoma, and basaloid squamous cell carcinoma in hope of improving clinical management and patient treatment. Diagn. Cytopathol. 2015;43:432-437.

AB - Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of MBCA in a 67-year-old female that was originally misinterpreted as adenoid cystic carcinoma (ACC) on FNA cytology. The FNA smears showed numerous uniform small basaloid epithelial cells with round or oval nuclei and inconspicuous nucleoli, and scant cytoplasm. The basaloid cells surround acellular, dense, homogenous material or are surrounded by acellular or paucicellular dense homogeneous material possibly containing bland spindle cells. The basaloid cells are present in variably sized three-dimensional clusters, acini, or sheets with variable cohesion. The dense homogenous material surrounded by basaloid cells may be interconnected. High power magnification reveals the homogeneous material to have a fibrillar texture. The edges of dense homogenous materials were well-demarcated. We describe the diagnostic pitfalls of FNA for MBCA, particularly versus ACC, basal cell adenoma, cellular pleomorphic adenoma, myoepithelioma, basal cell adenocarcinoma, and basaloid squamous cell carcinoma in hope of improving clinical management and patient treatment. Diagn. Cytopathol. 2015;43:432-437.

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KW - fine-needle aspiration

KW - membranous basal cell adenoma

KW - parotid

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