Objective: To determine whether placenta accreta/percreta/increta is associated with elevation of second-trimester maternal serum alpha-fetoprotein (MSAFP) levels. Methods: We reviewed the medical records of 44 women who had emergency cesarean hysterectomy. Twenty women had placenta accreta/percreta/increta (study group) and 24 underwent cesarean hysterectomy for other indications (control group). Pertinent maternal and neonatal variables were abstracted from the prenatal records and hospital charts. Chi-square and Fisher exact tests were used to analyze categorical variables. Student t test was used to analyze continuous variables. Results: Nine of 20 patients (45%) with placenta accreta/ percreta/increta and none of 24 subjects in the control group had an elevated MSAFP value (P < .001). Maternal estimated blood loss was also significantly greater in the study group (4469 ± 1851 versus 1885 ± 1113 mL; P < .0001), as was the number of blood units transfused (7.7 ± 4.7 versus 3.0 ± 2.2; P < .001). None of the other examined variables were different between the groups. Conclusions: A significant association exists between placenta accreta/percreta/increta and elevated MSAFP values. Patients with an unexplained elevation of MSAFP may have an increased risk for placenta accreta and associated blood loss at cesarean hysterectomy.
|Original language||English (US)|
|Number of pages||4|
|Journal||Obstetrics and gynecology|
|State||Published - Aug 1993|
ASJC Scopus subject areas
- Obstetrics and Gynecology