Placental and fetal findings in intrauterine Candida lusitaniae infection following in vitro fertilization and embryo transfer

Michael Huang, Elaine M. Cham, Carey S. Eppes, Susan E. Gerber, Kurt D. Reed, Linda M. Ernst*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Intrauterine infection with non-albicans Candida species is rare but can be catastrophic to the fetus. A subset of intrauterine infections with non-albicans Candida species has occurred in women who have undergone in vitro fertilization and embryo transfer (IVF-ET). We report a case of a 33-year-old healthy woman, pregnant with triplets by in vitro fertilization, who experienced preterm premature rupture of membranes of fetus A at 16 weeks' gestation and subsequently developed oligohydramnios in all 3 fetuses. Following elective pregnancy termination, microscopic examination and molecular analysis demonstrated Candida lusitaniae chorioamnionitis and pneumonia in all 3 fetuses associated with granulomatous inflammation. Our case is only the 2nd report of C. lusitaniae chorioamnionitis and should raise awareness that C. lusitaniae intrauterine infection is associated with IVF-ET. We also show here that C. lusitaniae can cause granulomatous intraplacental inflammation and intrauterine pneumonia.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalPediatric and Developmental Pathology
Volume15
Issue number2
DOIs
StatePublished - Jul 27 2012

Keywords

  • Amnionic fluid infection
  • Chorioamnionitis
  • Congenital pneumonia
  • Non-albicans Candida species

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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