Placental mesenchymal dysplasia without fetal development in a twin gestation: A case report and review of the spectrum of androgenetic biparental mosaicism

Rebecca L. Linn, Lucy Minturn, Lynn M. Yee, Kruti Maniar, Yanming Zhang, Michael K. Fritsch, Papreddy Kashireddy, Raj Kapur, Linda M. Ernst*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We report a dichorionic twin gestation with diffuse placental mesenchymal dysplasia (PMD) and androgenetic biparental mosaicism (ABM) involving one twin's placenta with complete absence of fetal development for that twin. To our knowledge, this is the 1st reported case of PMD without fetal development. We discuss the gross, histologic, and genetic hallmarks of PMD and the spectrum of variability depending on degree and distribution of ABM.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalPediatric and Developmental Pathology
Volume18
Issue number2
DOIs
StatePublished - Mar 1 2015

Keywords

  • Androgenetic biparental mosaicism
  • Hydatidiform mole
  • Placental mesenchymal dysplasia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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