Placental vascular maldevelopment, intrauterine growth restriction, and pulmonary hypertension

Maxwell Mathias*, Mireille Bitar, Monica Aldulescu, Robert Birkett, Marta Perez, Karen Mestan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A 33-year-old gravida 2, para 1 woman was noted to have early intrauterine growth restriction at 22 weeks gestation and subsequently developed severe pre-eclampsia. She delivered a 460 g male neonate at 28 weeks. The infant was managed on non-invasive ventilatory support and was gaining weight on enteral feeds for the first eight weeks of life, at which point he developed necrotizing enterocolitis. He then developed severe pulmonary hypertension that was refractory to maximal medical management. He died at 10 weeks of life due to hypoxemic respiratory and heart failure. Placental pathology revealed a constellation of findings consistent with maternal vascular malperfusion. Lung autopsy revealed muscularized and hypertrophied pulmonary arterioles consistent with severe pulmonary hypertension. Von Willebrand factor immunofluorescent staining of autopsy specimens suggest parallels in extent of endothelial injury. This case study illustrates our evolving knowledge of the fetal origins of neonatal lung diseases.

Original languageEnglish (US)
JournalPulmonary Circulation
Issue number4
StatePublished - 2020


  • developmental lung biology
  • neonatal lung disease and bronchopulmonary dysplasia
  • pregnancy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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