Plakins: A family of versatile cytolinker proteins

Conrad L. Leung; Kathleen J. Green; Ronald K.H. Liem

doi:10.1016/S0962-8924(01)02180-8

Plakins: A family of versatile cytolinker proteins

Conrad L. Leung^*, Kathleen J. Green, Ronald K.H. Liem

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

258 Scopus citations

Abstract

By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity. Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family. Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle. Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction.

Original language	English (US)
Pages (from-to)	37-45
Number of pages	9
Journal	Trends in Cell Biology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0962-8924(01)02180-8
State	Published - Jan 1 2002

Funding

Our work is supported by grants NS15182 and MDA to the Liem laboratory, and NIH grants AR43380, AR41836 and PO1 DE12328 (project 4) to the Green laboratory.

ASJC Scopus subject areas

Cell Biology

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10.1016/S0962-8924(01)02180-8

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abstract = "By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity. Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family. Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle. Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction.",

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N2 - By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity. Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family. Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle. Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction.

AB - By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity. Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family. Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle. Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction.

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Plakins: A family of versatile cytolinker proteins

Abstract

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