Plakophilins: multifunctional scaffolds for adhesion and signaling

Amanda E. Bass-Zubek*, Lisa Marie Godsel, Mario Delmar, Kathleen Janee Green

*Corresponding author for this work

Research output: Contribution to journalReview article

102 Scopus citations

Abstract

Armadillo family proteins known as plakophilins have been characterized as structural components of desmosomes that stabilize and strengthen adhesion by enhancing attachments with the intermediate filament cytoskeleton. However, plakophilins and their close relatives are emerging as versatile scaffolds for multiple signaling and metabolic processes that not only facilitate junction dynamics but also more globally regulate diverse cellular activities. While perturbation of plakophilin functions contribute to inherited diseases and cancer pathogenesis, the functional significance of the multiple PKP isoforms and the mechanisms by which their behaviors are regulated remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)708-716
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Cell Biology

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