Plakophilins: multifunctional scaffolds for adhesion and signaling

Amanda E. Bass-Zubek*, Lisa M. Godsel, Mario Delmar, Kathleen J. Green

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations


Armadillo family proteins known as plakophilins have been characterized as structural components of desmosomes that stabilize and strengthen adhesion by enhancing attachments with the intermediate filament cytoskeleton. However, plakophilins and their close relatives are emerging as versatile scaffolds for multiple signaling and metabolic processes that not only facilitate junction dynamics but also more globally regulate diverse cellular activities. While perturbation of plakophilin functions contribute to inherited diseases and cancer pathogenesis, the functional significance of the multiple PKP isoforms and the mechanisms by which their behaviors are regulated remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)708-716
Number of pages9
JournalCurrent Opinion in Cell Biology
Issue number5
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Cell Biology


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