Planar cell polarity acts through septins to control collective cell movement and ciliogenesis

Su Kyoung Kim, Asako Shindo, Tae Joo Park, Edwin C. Oh, Srimoyee Ghosh, Ryan S. Gray, Richard A. Lewis, Colin A. Johnson, Tania Attie-Bittach, Elias Nicholas Katsanis, John B. Wallingford

Research output: Contribution to journalArticlepeer-review

238 Scopus citations

Abstract

The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. The septins are cytoskeletal proteins controlling behaviors such as cell division and migration. Here, we identified control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in Xenopus embryos. We also linked mutations in human Fritz to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis. These findings shed light on the mechanisms by which fundamental cellular machinery, such as the cytoskeleton, is regulated during embryonic development and human disease.

Original languageEnglish (US)
Pages (from-to)1337-1340
Number of pages4
JournalScience
Volume329
Issue number5997
DOIs
StatePublished - Sep 10 2010

ASJC Scopus subject areas

  • General

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